Correlation of positron emission tomography standard uptake value and pathologic specimen size in cancer of the head and neck
Correlation of positron emission tomography standard uptake value and pathologic specimen size in cancer of the head and neck
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DOI：
10.1016/j.ijrobp.2007.10.055
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发表时间：
2008-07-01
影响因子：
7
通讯作者：
Kao, Johnny
中科院分区：
文献类型：
--
作者：
Burri, Ryan J.;Rangaswamy, Balasubramanya;Kao, Johnny
目的：相关的正电子发射断层扫描（PET）的标准摄取值（SUV）与病理标本大小的患者与头颈cancer.Methods和材料：18例II-IVB期头颈癌与27个肿瘤谁接受PET和计算机断层扫描（CT）成像的头部和颈部手术切除术后，被选为本研究。检查了各种SUV阈值，包括软件默认值（SUVdef）、将窗口缩小最大值的1个标准差（SD）（SUV-1 SD）、SUV临界值为2.5或更大（SUV 2.5）和40%或更大（SUV 40）。12例患者的体积病理学数据可用。根据病理检查（金标准）、CT、SUV def、SUV-1 SD、SUV 2.5和SUV 40分析肿瘤体积。PET鉴别原发性肿瘤的敏感性为94%（17/18）。PET对颈部分期的敏感性为90%（9/10），而特异性为78%（7/9）。SUV2.5的方法是最有可能高估肿瘤体积，而SUVdef和SUV-1 SD是最有可能低估tumor volume.Conclusions：PET扫描提供了更准确的分期原发肿瘤和淋巴结转移的晚期头颈癌患者比单独的CT。与金标准相比，使用不同SUV阈值获得的体积存在显著的变异性。临床、CT和PET数据的组合应继续用于最佳治疗计划。SUV 40方法似乎在准确性和降低低估肿瘤范围的风险之间提供了最佳折衷。(c)2008年爱思唯尔公司
Purpose: To correlate positron emission tomography (PET) standard uptake value (SUV) with pathologic specimen size in patients with head-and-neck cancers.Methods and Materials: Eighteen patients with Stage II-IVB head-and-neck cancer with 27 tumors who underwent PET and computed tomography (CT) imaging of the head and neck followed by surgical resection were selected for this study. Various SUV thresholds were examined, including the software default (SUVdef), narrowing the window by 1 standard deviation (SD) of the maximum (SUV-1SD), and SUV cutoff values of 2.5 or greater (SUV2.5) and 40% or greater maximum (SUV40). Volumetric pathologic data were available for 12 patients. Tumor volumes based on pathologic examination (gold standard), CT, SUVdef, SUV-1SD, SUV2.5, and SUV40 were analyzed.Results: PET identified five tumors not seen on CT. The sensitivity of PET for identifying primary tumors was 94% (17 of 18). The Sensitivity of PET for staging the neck was 90% (9 of 10), whereas the specificity was 78% (7 of 9). The SUV2.5 method was most likely to overestimate tumor volume, whereas SUVdef and SUV-1SD were most likely to underestimate tumor volume.Conclusions: The PET scan provides more accurate staging of primary tumors and nodal metastases for patients with advanced head-and-neck cancer than CT alone. Compared with the gold standard, significant variability exists in volumes obtained by using various SUV thresholds. A combination of clinical, CT, and PET data should continue to be used for optimal treatment planning. The SUV40 method appears to offer the best compromise between accuracy and reducing the risk of underestimating tumor extent. (c) 2008 Elsevier Inc.