Development of a broad spectrum polymer-released antimicrobial coating for the prevention of resistant strain bacterial infections.
Development of a broad spectrum polymer-released antimicrobial coating for the prevention of resistant strain bacterial infections.
复制标题
DOI：
10.1002/jbm.a.34209
复制
发表时间：
2012-10
影响因子：
4.9
通讯作者：
Bloebaum, R. D.
中科院分区：
文献类型：
--
作者：
Sinclair, K. D.;Pham, T. X.;Farnsworth, R. W.;Williams, D. L.;Loc-Carrillo, C.;Horne, L. A.;Ingebretsen, S. H.;Bloebaum, R. D.
在美国，每年进行的初次髋关节和膝关节置换手术超过40万例。在这些手术中，大约0.5-3%的人会被感染，当考虑重新手术时，这一比例被发现显著增加。耐药细菌感染是病人护理中一个日益严重的问题。这项体外研究考察了释放的广谱阳离子类固醇抗菌剂-13(CSA-13)对5×108个耐甲氧西林金黄色葡萄球菌(MRSA)集落形成单位(CFU)的抗菌潜力。据推测，当硅胶中CSA-13的重量比(w/w)为18%时，用作控释装置涂层时将显示出强大的杀菌潜力。当加入到聚合物设备涂层中时，18%(w/w)的广谱聚合物释放的CSA-13抗菌剂在8小时内消除了5×108CFU的MRSA。未来，这些结果将被用于开发绵羊模型，以评估CsA-13在体内预防围手术期装置相关感染的作用。
More than 400,000 primary hip and knee replacement surgeries are performed each year in the United States. From these procedures, approximately 0.5–3% will become infected and when considering revision surgeries, this rate has been found to increase significantly. Antibiotic resistant bacterial infections are a growing problem in patient care. This in vitro research investigated the antimicrobial potential of the polymer released, broad spectrum, Cationic Steroidal Antimicrobial-13 (CSA-13) for challenges against 5 × 108 colony forming units (CFU) of methicillin-resistant Staphylococcus aureus (MRSA). It was hypothesized that a weight-to-weight (w/w) concentration of 18% CSA-13 in silicone would exhibit potent bactericidal potential when used as a controlled release device coating. When incorporated into a polymeric device coating, the 18% (w/w) broad-spectrum polymer released CSA-13 antimicrobial eliminated 5 × 108 CFU of MRSA within 8 hours. In the future, these results will be utilized to develop a sheep model to assess CSA-13 for the prevention of perioperative device related infections in vivo.
登录
查看更多内容
影响因子：
4.2
作者：
Darwiche, Hussein;Barsoum, Wael K.;Molloy, Robert
通讯作者：
Molloy, Robert
影响因子：
4.9
作者：
Chin, Judy N.;Rybak, Michael J.;Savage, Paul B.
通讯作者：
Savage, Paul B.
影响因子：
11.8
作者：
Ambrose, Paul G.;Bhavnani, Sujata M.;Drusano, George L.
通讯作者：
Drusano, George L.
影响因子：
5.2
作者：
Chin, Judy N.;Jones, Ronald N.;Rybak, Michael J.
通讯作者：
Rybak, Michael J.
影响因子：
4.9
作者：
Epand, Raquel F.;Pollard, Jake E.;Epand, Richard M.
通讯作者：
Epand, Richard M.