Age-Associated Changes in the DNA of Mouse Tissue
Age-Associated Changes in the DNA of Mouse Tissue
复制标题
小鼠组织 DNA 与年龄相关的变化
作者：
G. Price;S. Modak;T. Makinodan
用小牛胸腺DNA聚合酶在年轻和衰老小鼠的固定脑、肝和心脏组织切片中研究了DNA的模板活性。该酶催化更大的脱氧核糖核苷酸单磷酸掺入老年小鼠神经元，星形胶质细胞，枯否细胞和心肌纤维的细胞核。结果被解释为DNA链断裂的积累与老化。
The template activity of DNA with calf thymus DNA polymerase has been studied in sections of fixed brain, liver, and heart tissues from young and senescent mice. The enzyme catalyzed greater incorporation of deoxyribonucleotide monophosphates into nuclei of old mouse neurons, astrocytes, Kupffer cells, and heart muscle fibers. The results are interpreted as the accumulation of DNA strand breaks with aging.