SMOKING AND INFLAMMATORY BOWEL-DISEASE - A CASE CONTROL STUDY
SMOKING AND INFLAMMATORY BOWEL-DISEASE - A CASE CONTROL STUDY
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DOI：
10.1136/gut.29.3.352
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发表时间：
1988-03-01
期刊：
影响因子：
24.5
通讯作者：
JARNEROT, G
中科院分区：
文献类型：
--
作者：
LINDBERG, E;TYSK, C;JARNEROT, G
对260例溃疡性结肠炎和144例克罗恩病患者进行了诊断时吸烟习惯的人群病例对照研究。与从不吸烟者相比，吸烟者患溃疡性结肠炎的风险降低（相对风险0.7），这似乎是剂量依赖性的。在以前吸烟的人中，观察到反弹效应，特别是在以前的重度吸烟者中，风险急剧增加（相对风险4.4）。未记录到性别差异。吸烟使患克罗恩病的风险增加一倍，没有任何剂量依赖性模式。在前吸烟者中观察到非显著增加的风险。这可能是由戒烟后的遗留效应引起的，然而，这可能会随着时间的推移而减少。未观察到性别差异。
A population case controlled study of smoking habits at the time of diagnosis was done in 260 patients with ulcerative colitis and 144 with Crohn''s disease. Smokers had a decreased risk of acquiring ulcerative colitis in comparison with never smokers (relative risk 0.7) which appeared to be dose dependent. In former smokers a rebound effect was seen, especially in former heavy smokers, where the risk was sharply increased (relative risk 4.4.). No sex difference was recorded. Smoking doubled the risk of acquiring Crohn''s disease without any dose dependent pattern. In former smokers a non-significantly increased risk was observed. This might be caused by a carry over effect after stopping smoking, however, which possibly is reduced by time. No sex difference was seen.