An integrated microfluidic device for influenza and other genetic analyses
An integrated microfluidic device for influenza and other genetic analyses
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DOI：
10.1039/b505994a
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发表时间：
2005-01-01
期刊：
影响因子：
6.1
通讯作者：
Burns, MA
中科院分区：
文献类型：
--
作者：
Pal, R;Yang, M;Burns, MA
已经开发了能够进行各种遗传测定的集成微流体装置，作为建立用于广泛传播的系统的一个步骤。该设备集成了流体和热组件，如加热器，温度传感器和可寻址阀，以控制串联的两个纳升反应器，然后进行电泳分离。这种组分的组合适用于各种遗传分析。例如，我们已经成功鉴定了流感病毒A/LA/1/87株的序列特异性血凝素A亚型。该设备采用紧凑的设计和大规模生产技术，使其成为各种广泛传播应用的有吸引力的平台。
An integrated microfluidic device capable of performing a variety of genetic assays has been developed as a step towards building systems for widespread dissemination. The device integrates fluidic and thermal components such as heaters, temperature sensors, and addressable valves to control two nanoliter reactors in series followed by an electrophoretic separation. This combination of components is suitable for a variety of genetic analyses. As an example, we have successfully identified sequence-specific hemagglutinin A subtype for the A/LA/1/87 strain of influenza virus. The device uses a compact design and mass production technologies, making it an attractive platform for a variety of widely disseminated applications.