Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure
Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure
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DOI：
10.1016/j.jacc.2006.07.073
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发表时间：
2007-02-13
影响因子：
24
通讯作者：
Sobotka, Paul A.
中科院分区：
文献类型：
--
作者：
Costanzo, Maria Rosa;Guglin, Maya E.;Sobotka, Paul A.
目的 本研究旨在比较静脉-静脉超滤和标准静脉利尿治疗对高容量性心力衰竭 (HF) 患者的安全性和有效性。 背景 对于失代偿性心力衰竭和容量超负荷的患者，早期超滤可能是静脉利尿剂的替代方案。 方法 因 HF 住院且有 >= 2 种高血容量迹象的患者被随机分配使用超滤或静脉利尿剂。主要终点是随机分组后 48 小时的体重减轻和呼吸困难评估。次要终点包括 48 小时的净失水量、功能能力、心力衰竭再住院和 90 天内的计划外就诊。安全终点包括肾功能、电解质和血压的变化。 结果 200 名患者（63 +/- 15 岁，69% 为男性，射血分数为 71%）
Objectives This study was designed to compare the safety and efficacy of veno-venous ultrafiltration and standard intravenous diuretic therapy for hypervolemic heart failure (HF) patients.Background Early ultrafiltration may be an alternative to intravenous diuretics in patients with decompensated HF and volume overload.Methods Patients hospitalized for HF with >= 2 signs of hypervolemia were randomized to ultrafiltration or intravenous diuretics. Primary end points were weight loss and dyspnea assessment at 48 h after randomization. Secondary end points included net fluid loss at 48 h, functional capacity, HF rehospitalizations, and unscheduled visits in 90 days. Safety end points included changes in renal function, electrolytes, and blood pressure.Results Two hundred patients (63 +/- 15 years, 69% men, 71% ejection fraction