ARTICULAR MASTOCYTOSIS IN RHEUMATOID-ARTHRITIS
ARTICULAR MASTOCYTOSIS IN RHEUMATOID-ARTHRITIS
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类风湿关节炎的关节肥大细胞增多症
DOI：
10.1002/art.1780270802
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
KRANE, SM
中科院分区：
文献类型：
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作者：
CRISP, AJ;CHAPMAN, CM;KRANE, SM
肥大细胞的数量和分布进行了评估，在116例滑膜类风湿关节炎患者和30个对照标本。风湿性关节炎滑膜平均含有48.5个肥大细胞/20个高倍视野（HPF）（范围0-252），对照滑膜平均含有3.9个肥大细胞/20个HPF（范围0-13）（P < 0.001）。在类风湿性关节炎的高和低肥大细胞亚群的比较中，计数与受影响关节的临床滑膜炎的强度直接相关，但与Hb浓度或红细胞沉降率无关。5例类风湿性关节炎患者的关节表现为骨重建活跃，类骨质增多，破骨细胞吸收活跃，骨小梁骨质疏松。肥大细胞在骨外血管翳和骨内浸润组织中均显著。肥大细胞在类风湿性关节炎发病机制中的可能作用进行了讨论。
The number and distribution of mast cells were assessed in 116 synovial membranes from patients with rheumatoid arthritis and in 30 control specimens. Rheumatoid synovial membranes contained a mean of 48.5 mast cells/20 high-power fields (HPF) (range 0-252), and control synovial membranes had a mean of 3.9 mast cells/20 HPF (range 0-13) (P < 0.001). In a comparison of high and low mast cell subgroups in rheumatoid arthritis, counts were directly related to the intensity of clinical synovitis in the affected joint, but not to Hb concentration or erythrocyte sedimentation rate. Joints excised from 5 patients with rheumatoid arthritis were characterized by active bone remodeling with increased osteoid, active resorption by osteoclasts and trabecular osteoporosis. Mast cells were prominent in both extraosseous pannus and intraosseous invasive tissue. The possible roles of mast cells in the pathogenesis of rheumatoid arthritis are discussed.