Watermaze learning enhances excitability of CA1 pyramidal neurons
Watermaze learning enhances excitability of CA1 pyramidal neurons
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DOI：
10.1152/jn.01177.2002
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发表时间：
2003-10-01
影响因子：
2.5
通讯作者：
Disterhoft, JF
中科院分区：
文献类型：
--
作者：
Oh, MM;Kuo, AG;Disterhoft, JF
背侧海马是学习的关键隐藏平台的位置在海马依赖的空间水迷宫任务。我们以前已经证明，postburst后超极化（AHP）的海马锥体神经元收购后，减少了海马依赖性，时间跟踪眨眼条件反射任务。我们在这里报告的AHP和一个或多个相关的电流（I-AHP和/或SI（AHP））减少背海马CA 1锥体神经元的大鼠学习水迷宫任务相比，从控制大鼠的神经元。这种减少是一种学习诱导的现象，因为未能学习隐藏平台位置的大鼠的CA 1神经元的AHP与对照大鼠的神经元相似。我们提出，减少的AHP在锥体神经元的区域学习的关键是一个细胞的学习机制，是保守的跨物种和任务。
The dorsal hippocampus is crucial for learning the hidden-platform location in the hippocampus-dependent, spatial watermaze task. We have previously demonstrated that the postburst afterhyperpolarization (AHP) of hippocampal pyramidal neurons is reduced after acquisition of the hippocampus-dependent, temporal trace eyeblink conditioning task. We report here that the AHP and one or more of its associated currents (I-AHP and/or sI(AHP)) are reduced in dorsal hippocampal CA1 pyramidal neurons from rats that learned the watermaze task as compared with neurons from control rats. This reduction was a learning-induced phenomenon as the AHP of CA1 neurons from rats that failed to learn the hidden-platform location was similar to that of neurons from control rats. We propose that reduction of the AHP in pyramidal neurons in regions crucial for learning is a cellular mechanism of learning that is conserved across species and tasks.