The effect of water diuresis and antidiuretic hormone on the regional renal red cell flow.
The effect of water diuresis and antidiuretic hormone on the regional renal red cell flow.
复制标题
水利尿和抗利尿激素对局部肾红细胞流量的影响。
DOI：
10.1111/j.1748-1716.1974.tb05577.x
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
P. Wunderlich
中科院分区：
文献类型：
--
作者：
A. Persson;J. Schnermann;H. Ulfendahl;M. Wolgast;P. Wunderlich
本研究以9只杂种犬为研究对象，采用指示剂稀释技术，用小针状半导体检测器检测32-P标记红细胞，探讨肾髓质血流动力学在高渗和低渗尿液形成中的可能作用。红细胞流量由
The possible role of the renal medullary hemodynamics in the formation of hypertonic and hypotonic urine was examined in 9 mongrel dogs, using an indicator-dilution technique with 32-P labelled red cells internal detection with small needle-shaped semiconductor detectors. The red cell flow was estimated from
a) the mean transit time calculated by dividing the area of the indicator-dilution curve by the peak activity and
b) the regional red cell volume determined as the ratio of intrarenal equilibrium activity to red cell equilibrium activity in whole blood.
In water diuresis, as induced by 200–400 ml of a hypotonic saline-glucose solution, the red cell flow showed a small and barely significant increase estimated at 19 %, 18 % and 10 % for the cortical, outer medullary and inner medullary circulations, respectively. After the administration of antidiuretic hormone at a rate of 1.5 mU/min and kg the cortical and outer medullary red cell flows (but not the inner medullary) were significantly reduced towards the control values. It is concluded that the conditions of water diuresis and antidiuresis as due to the action of ADH are not accompanied by marked changes in the renal medullary blood flow.