Optimal number of stimulation contacts for coordinated reset neuromodulation.
Optimal number of stimulation contacts for coordinated reset neuromodulation.
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DOI：
10.3389/fneng.2013.00005
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Tass PA
中科院分区：
文献类型：
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作者：
Lysyansky B;Popovych OV;Tass PA
在这项计算研究中，我们研究了协调重置（CR）神经调节，旨在通过对神经元目标群体的多位点刺激来有效控制同步。建议该方法有效抵消几种神经系统疾病的病理性神经元同步特征。我们研究了最佳 CR 诱导的去同步化需要多少刺激位点。我们发现，刺激完全关闭后，适度增加刺激部位的数量可能会显着延长刺激后失同步瞬态。反过来，这可以减少间歇性 ON-OFF CR 刺激方案所施加的刺激电流量，其中刺激开启的时间间隔后面循环地跟随刺激关闭的时间间隔。此外，我们发现刺激部位的最佳数量本质上取决于随着距刺激部位距离的增加，所施加的电流在神经元组织内衰减的强度。特别地，对于广泛的空间刺激分布，即，对于刺激电流的弱空间衰减率，CR刺激可以最佳地通过少量刺激位点传递。我们的研究结果可能有助于优化 CR 神经调节的治疗应用。
In this computational study we investigate coordinated reset (CR) neuromodulation designed for an effective control of synchronization by multi-site stimulation of neuronal target populations. This method was suggested to effectively counteract pathological neuronal synchrony characteristic for several neurological disorders. We study how many stimulation sites are required for optimal CR-induced desynchronization. We found that a moderate increase of the number of stimulation sites may significantly prolong the post-stimulation desynchronized transient after the stimulation is completely switched off. This can, in turn, reduce the amount of the administered stimulation current for the intermittent ON–OFF CR stimulation protocol, where time intervals with stimulation ON are recurrently followed by time intervals with stimulation OFF. In addition, we found that the optimal number of stimulation sites essentially depends on how strongly the administered current decays within the neuronal tissue with increasing distance from the stimulation site. In particular, for a broad spatial stimulation profile, i.e., for a weak spatial decay rate of the stimulation current, CR stimulation can optimally be delivered via a small number of stimulation sites. Our findings may contribute to an optimization of therapeutic applications of CR neuromodulation.