Prognostic Relevance of c-Myc and BMI1 Expression in Patients With Glioblastoma
Prognostic Relevance of c-Myc and BMI1 Expression in Patients With Glioblastoma
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DOI：
10.1309/ajcprxhnjqlo09qa
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发表时间：
2012-09-01
影响因子：
3.5
通讯作者：
Larocca, Luigi Maria
中科院分区：
文献类型：
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作者：
Cenci, Tonia;Martini, Maurizio;Larocca, Luigi Maria
虽然c-Myc癌基因在人类癌症中经常失调，但其参与胶质母细胞瘤的发病机制尚不清楚。我们对48例胶质母细胞瘤患者进行了c-Myc、多梳环指癌基因（BMI 1）和组蛋白3赖氨酸9（H3 K9 Ac）乙酰化的免疫组化分析，这些患者接受了手术，随后接受了放疗和替莫唑胺治疗。c-Myc、BMI 1和H3 K9 ac的表达与临床特征和预后相关。我们发现c-Myc的过度表达与BMI 1的过度表达显著相关（P = 0.009），并且具有过度表达c-Myc和BMI 1的胶质母细胞瘤的患者显示出显著更长的总生存期（分别为P <0.0001和P = 0.0009）。我们的研究结果提供了c-Myc和相关基因在胶质母细胞瘤患者中的预后价值的第一个证据。c-Myc和BMI 1表达对生存的有利影响可能是通过激活凋亡途径使癌细胞对放疗和替莫唑胺敏感而介导的。
Although the c-Myc oncogene is frequently deregulated in human cancer, its involvement in the pathogenesis of glioblastoma is not clear. We conducted immunohistochemical analysis of the expression of c-Myc, polycomb ring finger oncogene (BMI1), and acetylation of the lysine 9 (H3K9Ac) of histone 3 in 48 patients with glioblastoma who underwent surgery followed by radiotherapy and temozolomide treatment. The expression of c-Myc, BMI1, and H3K9ac was correlated with clinical characteristics and outcome. We found that overexpression of c-Myc was significantly associated with that of BMI1 (P = .009), and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival (P < .0001 and P = .0009, respectively). Our results provide the first evidence of the prognostic value of c-Myc and associated genes in patients with glioblastoma. The favorable effect of c-Myc and BMI1 expression on survival is likely mediated by the sensitization of cancer cells to radiotherapy and temozolomide through the activation of apoptotic pathways.