The functional role of the renin-angiotensin system in pregnancy and preeclampsia.
The functional role of the renin-angiotensin system in pregnancy and preeclampsia.
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DOI：
10.1016/j.placenta.2008.06.011
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发表时间：
2008-09
期刊：
影响因子：
3.8
通讯作者：
Xia, Y.
中科院分区：
文献类型：
--
作者：
Irani, R. A.;Xia, Y.
关键词：
在正常妊娠期间，肾素-血管紧张素系统（RAS）在盐平衡和随后的母亲和胎儿的健康中起着至关重要的作用。在这种平衡中，不仅要考虑经典的肾脏RAS，还要考虑子宫胎盘单位的RAS，其中母体和胎儿组织都有助于信号级联反应。许多研究表明，在正常妊娠中，RAS的几乎所有成分都增加。在怀孕的混乱中，这种微妙的平衡可能变得不平衡。先兆子痫就是这样一种情况。它是一种妊娠期疾病，以高血压、蛋白尿和胎盘异常为特征，与滋养细胞浅浸润和螺旋动脉重塑受损相关。尽管是孕产妇死亡的主要原因和孕产妇和围产期发病率的主要贡献者，负责先兆子痫的发病机制知之甚少。长期以来，免疫机制和RAS一直被认为与先兆子痫的发生有关。许多最近的研究表明存在血管紧张素II I型受体激动性自身抗体（AT 1-AA）。这种自身抗体可以诱导疾病的许多关键特征，并上调参与先兆子痫发病机制的分子。本文就RAS在妊娠期的作用以及AT 1-AA对子痫前期的影响进行综述。
During normal pregnancy, the renin-angiotensin system (RAS) plays a vitally important role in salt balance and subsequent well-being of mother and fetus. In this balance, one must consider not only the classical renal RAS but also that of the uteroplacental unit, where both maternal and fetal tissues contribute to the signaling cascade. Many studies have shown that in normal pregnancy there is an increase in almost all of the components of the RAS. In derangements of pregnancy this delicate equilibrium can become unbalanced. Preeclampsia is one such case. It is a disorder of pregnancy characterized by hypertension, proteinuria and placental abnormalities associated with shallow trophoblast invasion and impaired spiral artery remodeling. Despite being a leading cause of maternal death and a major contributor to maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are poorly understood. Immunological mechanisms and the RAS have been long considered to be involved in the development of preeclampsia. Numerous recent studies demonstrate the presence of the angiotensin II type I receptor agonistic autoantibody (AT1-AA). This autoantibody can induce many key features of the disorder and upregulate molecules involved in the pathogenesis of preeclampsia. Here we review the functional role of the RAS during pregnancy and the impact of AT1-AA on preeclampsia.
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