Five year study of cardiovascular risk factors in Japanese people: implications concerning new onset of metabolic syndrome.
Five year study of cardiovascular risk factors in Japanese people: implications concerning new onset of metabolic syndrome.
复制标题
日本人心血管危险因素的五年研究：对新发代谢综合征的影响。
作者：
Akiko Suzuki;Keiichiro Kosuge;Osamu Nanyu;Hiroshi Watanabe;Toru Watanabe;Y. Usuda;Shigeru Sasaki;Y. Aizawa
背景
代谢综合征(METS)的发病率尚未得到充分研究。
方法和结果
对1996年和2001年接受体检的35534名受试者的数据进行了分析。由于没有腰围，METS的标准被用于那些有以下三项或三项以上的人：1)身体质量指数(BMI)和GT；或=25公斤/米(2)；2)血压>；或=130毫米汞柱(收缩和/或>)；或=85毫米汞(舒张压)；3)甘油三酯和GT；或=150毫克/分升；4)高密度脂蛋白(HDL)胆固醇；或=40毫克/分升(男性)；或=50毫克/分升(女性)；和5)空腹血糖(FBG)和GT；或=100毫克/分升。接受高血压、糖尿病和高甘油三酯治疗的受试者被认为有这些项目。用COX比例风险模型评价甲胎蛋白5年以上的发病率和危险性。在整整5年的随访期中，在30623名基线未发现甲状旁腺素的受试者中，有2853人(9.32%)发生了甲亢症。患代谢综合征的受试者年龄较大，体重指数、血压、甘油三酯和空腹血糖升高(P<；0.001)，高密度脂蛋白降低(男性为0.034，女性为0.001)。甲硫氨酸及其组合的每一项都与患甲亢症的风险较高相关。肥胖(BMI和GT；或=25 kg/m(2))单独或合并其他项目与患Met的风险更高相关，这表明它起着关键作用。
结论
使用BMI的METS在5年内的发病率为9.32%，即1.86%/年。METS的每一项或其组合都显示出患METS的高风险。肥胖与罹患甲亢症的风险比较高有关。
BACKGROUND
The incidence of metabolic syndrome (MetS) has not been fully studied.
METHODS AND RESULTS
The data of 35,534 subjects who underwent a health examination both in 1996 and 2001 were analyzed. Since the waist circumference was not available, modified criteria of MetS was used for those with 3 or more of the following items: 1) body mass index (BMI) >or=25 kg/m(2), 2) blood pressure >or=130 mm Hg in systolic and/or >or=85 mm Hg in diastolic, 3) triglycerides >or=150 mg/dL, 4) high-density lipoprotein (HDL) cholesterol <or=40 mg/dL in men, <or=50 mg/dL in women, and 5) fasting blood glucose (FBG) >or=100 mg/dL. The subjects who underwent therapy for hypertension, diabetes mellitus, and high TG were considered to have these items. The incidence of MetS over 5 years was determined and its risks were evaluated by Cox proportional-hazards models. During the follow-up of exactly 5 years, MetS developed in 2,853 (9.32%) among 30,623 subjects who had no MetS at baseline. The subjects who developed MetS were older, and had elevated BMI, blood pressure, TG and FBG (p<0.001 for all) and lower HDL (p<0.034 for men and p<0.001 for women). Each item of MetS and their combination was associated with a higher risk to develop MetS. Obesity (BMI >or=25 kg/m(2)) alone or in combination with another item was associated with a higher risk to develop MetS suggesting it plays a key role.
CONCLUSION
MetS using BMI developed in 9.32% over 5 years or 1.86%/year. Each item of MetS or their combination showed a high risk to develop MetS. Obesity was associated with a higher hazard ratio to develop MetS.
影响因子：
13.6
作者：
Kurella, M;Lo, JC;Chertow, GM
通讯作者：
Chertow, GM
影响因子：
16.2
作者：
Lorenzo, C;Okoloise, M;Haffner, SM
通讯作者：
Haffner, SM