BROMINATING OXIDANTS GENERATED BY HUMAN EOSINOPHILS
BROMINATING OXIDANTS GENERATED BY HUMAN EOSINOPHILS
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DOI：
10.1126/science.3018933
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发表时间：
1986-10-10
期刊：
影响因子：
56.9
通讯作者：
REGIANI, S
中科院分区：
文献类型：
--
作者：
WEISS, SJ;TEST, ST;REGIANI, S
嗜酸性粒细胞是白色血细胞，在人体中发现与蠕虫感染和各种炎症性疾病过程相关。这些细胞含有一种独特的溶酶体过氧化物酶，可以氧化卤化物，产生高活性和毒性的次卤酸。虽然在体内发现氯化物的浓度至少比其他卤化物高1000倍，但在生理条件下，人嗜酸性粒细胞并不优先氧化氯化物。相反，嗜酸性粒细胞使用溴化物，一种迄今为止在人类中具有未知功能的卤化物，产生一种卤化氧化剂，其特征与次溴酸相似，如果不是完全相同的话。这些结果表明，生理浓度的溴化物使人嗜酸性粒细胞具有产生和释放破坏广泛的原核和真核靶的不寻常的氧化剂胶囊的能力。
Eosinophils are white blood cells that in humans are found in association with helminthic infections and various inflammatory disease processes. These cells contain a unique lysosomal peroxidase that oxidizes halides to generate highly reactive and toxic hypohalous acids. Although chloride is found in vivo at concentrations at least 1000-fold greater than those of other halides, human eosinophils did not preferentially oxidize chloride under physiologic conditions. Instead, eosinophils used bromide, a halide with a hitherto unknown function in humans, to generate a halogenating oxidant with characteristics similar, if not identical, to those of hypobromous acid. These results indicate that physiological concentrations of bromide arm human eosinophils with the ability to generate and release an unusual oxidant capsule of destroying a wide range of prokaryotic and eukaryotic targets.