Comparison of Laparoscopic Microwave to Radiofrequency Ablation of Small Hepatocellular Carcinoma (≤3 cm).
Comparison of Laparoscopic Microwave to Radiofrequency Ablation of Small Hepatocellular Carcinoma (≤3 cm).
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DOI：
10.1245/s10434-016-5527-2
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发表时间：
2017-01
影响因子：
3.7
通讯作者：
Opocher E
中科院分区：
文献类型：
--
作者：
Santambrogio R;Chiang J;Barabino M;Meloni FM;Bertolini E;Melchiorre F;Opocher E
腹腔镜热消融术是治疗肝脏肿瘤的一种常见替代手术切除术，特别是在那些位于难以到达的位置。本研究旨在比较腹腔镜射频消融（RFA）和微波消融（MWA）治疗肝细胞癌（HCC）的安全性和长期疗效。从2009年2月至2015年5月，检查了接受腹腔镜MWA或腹腔镜RFA的HCC结节患者的数据。比较两组的并发症、完全消融率、局部肿瘤进展（LTP）率、无病生存率和累积生存率。共154例HCC患者（60例MWA和94例RFA）通过腹腔镜方法进行治疗。RFA组和MWA组的严重并发症发生率分别为1%和2%（p=0.747）。两个治疗组的完全消融率均为95%（p=0.931），RFA组的LTP率为21.2%，MWA组为8.3%（p=0.034）。RFA组和MWA组的5年无病生存率分别为19%和12%（p=0.434），而RFA组和MWA组的5年累积生存率分别为50%和37%（p=0.185）。腹腔镜RFA和MWA在治疗早期HCC中似乎是安全的。腹腔镜MWA组的局部肿瘤进展率低于腹腔镜RFA组，但其各自的总生存率和无病生存率保持相似。
Laparoscopic thermal ablation is a common alternative to surgical resection in treating hepatic tumors, particularly in those located in difficult-to-reach locations. The aim of this study was to compare the safety and long-term efficacy of laparoscopic radiofrequency ablation (RFA) and microwave ablation (MWA) in treating hepatocellular carcinoma (HCC). From February 2009 to May 2015, data from patients with HCC nodules who had undergone either laproscopic MWA or laparoscopic RFA were examined. Complications, complete ablation rates, local tumor progression (LTP) rates, disease-free survival and cumulative survival rates were compared between the two treatment groups. A total of 154 patients with HCC (60 MWA and 94 RFA) were treated via laparoscopic approach. Major complication rates were found to be 1% and 2% in the RFA group and the MWA group, respectively (p=0.747). Complete ablation rates were 95% for both treatment groups (p=0.931) and LTP rates were 21.2% for RFA and 8.3% for MWA (p=0.034). Disease-free survival rates at 5 years were 19% in the RFA group and 12% in the MWA group, respectively (p=0.434), while cumulative survival rates at 5 years were 50% in the RFA group and 37% in the MWA group, respectively (p=0.185). Laparoscopic RFA and MWA appear to be safe in the treatment of early-stage HCC. The local tumor progression rates was lower in the laparoscopic MWA compared to the laparoscopic RFA group but their respective overall survival and disease-free survival rates remained similar.
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影响因子：
9
作者：
Lo, CM;Lai, ECS;Wong, J
通讯作者：
Wong, J
影响因子：
2.9
作者：
de la Serna, Sofia;Vilana, Ramon;Garcia-Valdecasas, Juan-Carlos
通讯作者：
Garcia-Valdecasas, Juan-Carlos
DOI：
10.1097/meg.0000000000000270
发表时间：
2015-03-01
影响因子：
2.1
作者：
Chinnaratha, Mohamed A.;Sathananthan, Dharshan;Wigg, Alan J.
通讯作者：
Wigg, Alan J.
DOI：
10.1097/01.rvi.0000092666.72261.6b
发表时间：
2003-10-01
影响因子：
2.9
作者：
Lu, DSK;Raman, SS;Sayre, J
通讯作者：
Sayre, J
影响因子：
1.4
作者：
Lubner, Meghan G.;Brace, Christopher L.;Lee, Fred T., Jr.
通讯作者：
Lee, Fred T., Jr.