Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities.
Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities.
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DOI：
10.1615/critrevbiomedeng.v40.i1.20
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发表时间：
2012
影响因子：
--
通讯作者：
Roth CM
中科院分区：
文献类型：
--
作者：
Waite CL;Roth CM
抗癌药物对实体瘤的渗透性差显著限制了它们的功效。这种现象在小分子化疗药物中已经观察到很久了，在纳米级治疗中可能更加明显。纳米颗粒具有巨大的潜力，用于治疗癌症，由于其广泛的适用性作为药物输送和成像车辆和其尺寸依赖性的积累到实体瘤的增强渗透性和保留（EPR）的效果。此外，合成纳米颗粒可以被设计成克服药物递送的障碍。尽管它们有望用于治疗癌症，但在研究和提高它们在肿瘤脉管系统中被动积累后扩散到实体瘤中的能力方面做的工作相对较少。在这篇综述中，我们提出了复杂的问题，有效的渗透到实体肿瘤的纳米治疗。描述了研究人员研究纳米颗粒渗透到恶性肿瘤中的当前方法，并总结了研究纳米材料渗透到实体肿瘤中的最新工作。最后，我们概述了重要的纳米粒子设计参数控制其肿瘤渗透，以及突出在这一领域的关键方向。
Poor penetration of anticancer drugs into solid tumors significantly limits their efficacy. This phenomenon has long been observed for small-molecule chemotherapeutics, and it can be even more pronounced for nanoscale therapies. Nanoparticles have enormous potential for the treatment of cancer due to their wide applicability as drug delivery and imaging vehicles and their size-dependent accumulation into solid tumors by the enhanced permeability and retention (EPR) effect. Further, synthetic nanoparticles can be engineered to overcome barriers to drug delivery. Despite their promise for the treatment of cancer, relatively little work has been done to study and improve their ability to diffuse into solid tumors following passive accumulation in the tumor vasculature. In this review, we present the complex issues governing efficient penetration of nanoscale therapies into solid tumors. The current methods available to researchers to study nanoparticle penetration into malignant tumors are described, and the most recent works studying the penetration of nanoscale materials into solid tumors are summarized. We conclude with an overview of the important nanoparticle design parameters governing their tumor penetration, as well as by highlighting critical directions in this field.