THERMAL SENSITIVITY OF POLYMODAL NOCICEPTORS IN MONKEY
THERMAL SENSITIVITY OF POLYMODAL NOCICEPTORS IN MONKEY
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DOI：
10.1113/jphysiol.1976.sp011644
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发表时间：
1976-01-01
影响因子：
5.5
通讯作者：
KENSHALO, DR
中科院分区：
文献类型：
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作者：
CROZE, S;DUCLAUX, R;KENSHALO, DR
1. 通过记录初级神经纤维的活动，研究了麻醉猴毛皮肤中多模式伤害感受器对热和机械刺激的静态和动态敏感性。 2.多模式伤害感受器对皮肤刺痛、捏捏和加热至高于40摄氏度的温度有反应。它们对触摸、拉伸或寒冷没有反应。它们的轴突的传导速度为0.6至1.1m/秒。 3.观察到三种类型的皮肤感受野：1-2mm2的单点状区域； 1‐2 mm2 的多个点状区域；以及高达 25 mm2 的更大区域，具有不同的灵敏度。 4. 多模式伤害感受器受到从 33 或 37 摄氏度适应温度开始的热刺激。一系列实验包括以 0.2 摄氏度/秒的恒定速率将它们的感受野从一个或另一个适应温度加热到 43、45、47 和 50 摄氏度。每个热刺激强度维持4分钟，然后皮肤恢复到适应温度。在第一个系列之后，立即重复相同的系列，以确定先前加热对重新加热的动态响应的影响。动态响应分为三个阶段：在皮肤温度阈值水平处开始放电；超阈值变化期间的动态放电，当温度达到最大值时达到峰值频率；以及温度保持在高强度时的适应阶段。适应最初很快，然后在高强度的最后几分钟减慢。 5. 在热刺激之前将感受野调整至 33 摄氏度或 37 摄氏度不会影响多峰伤害器的敏感性和放电模式。 6. 在第一系列刺激期间，个体多模式伤害感受器开始对热刺激放电的阈值从 40 到 46.5 摄氏度不等。群体的平均阈值是 42.5 摄氏度。 7. 当比较对 0.2 和 1.5 摄氏度/秒的加热速率的反应时，没有观察到阈值的变化...
1. The static and dynamic sensitivities to thermal and mechanical stimuli of polymodal nociceptors in hairy skin of the anaesthetized monkey have been investigated by recording activity in their primary nerve fibres. 2. Polymodal nociceptors responded to skin pricking, pinching and heating to temperatures higher than 40 degrees C. They did not respond to touch, stretch or cold. The conduction velocity of their axons was from 0.6 to 1.1 m/sec. 3. Three types of cutaneous receptive fields have been observed: single spot‐like areas of 1‐2 mm2; multiple spot‐like areas of 1‐2 mm2; and larger areas up to 25 mm2 with heterogeneous sensitivity. 4. Polymodal nociceptors were subjected to heat stimuli that commenced from a 33 or 37 degrees C adapting temperature. A series consisted of heating their receptive fields to 43, 45, 47 and 50 degrees C from one or the other adapting temperatures at a constant rate of 0.2 degrees C/sec. Each heat stimulus intensity was maintained for 4 min after which the skin was returned to the adapting temperature. Immediately after the first series the identical series was repeated in order to determine the effect of prior heating upon the dynamic responses to re‐heating. The dynamic responses were characterized by three phases: an initiation of a discharge at a threshold level of skin temperature; a dynamic discharge during the suprathreshold change, that reached a peak frequency when the temperature reached its maximum; and an adaptation phase while the temperature remained at the high intensity. Adaptation was rapid initially, and then slowed during the final minutes at the high intensity. 5. Adapting the receptive field to either 33 degrees C or to 37 degrees C before the heat stimuli did not affect the sensitivity and the discharge pattern of the polymodal nocicpetors. 6. During the first series of stimulations, the threshold at which the individual polymodal nociceptors began to discharge to heat stimuli varied from 40 to 46.5 degrees C. The mean threshold of the population was 42.5 degrees C. 7. No change in the threshold was observed when responses to 0.2 and 1.5 degrees C/sec rates of heating were compared...