HIGH PREVALENCE OF HYPERTENSION IN SLEEP-APNEA PATIENTS INDEPENDENT OF OBESITY
HIGH PREVALENCE OF HYPERTENSION IN SLEEP-APNEA PATIENTS INDEPENDENT OF OBESITY
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DOI：
10.1164/ajrccm.150.1.8025776
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发表时间：
1994-07-01
影响因子：
24.7
通讯作者：
PETERSON, LE
中科院分区：
文献类型：
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作者：
CARLSON, JT;HEDNER, JA;PETERSON, LE
研究了377名连续进入睡眠实验室的受试者的体重指数（BMI）和睡眠呼吸暂停（SA）对血压和高血压患病率的相对影响。在患者中，124例（33%）患有SA，153例（41%）肥胖，93例（25%）患有全身性高血压。在未服用降压药的患者中，氧减饱和度（OD）和最低氧饱和度（Sa（O2 min））均与BMI相关（p < 0.001）。收缩压和舒张压与BMI和疾病严重程度相关。此外，随诊血压、高血压发生率、OD、Sa（O2 min）均与年龄有显著相关性。在多因素Logistic回归分析中，年龄、BMI和SA均被确定为高血压的独立预测因素。与年龄相关的相对危险度为4.3（40 ~ 59岁），与肥胖相关的相对危险度为2.7（大于或等于27 kg/m2），与SA相关的相对危险度为2.1（> 30次去饱和/6 h）。高血压的相对危险度随着年龄和BMI的增加而增加。然而，在SA中，去饱和次数较多的患者（OD大于或等于60，2.2）的相对风险没有变化。合并肥胖和SA导致高血压患病率增加3.9倍。我们的结论是，年龄，SA和超重是发展为系统性高血压的独立和附加的危险因素。
The relative influence of body mass index (BMI) and sleep apnea (SA) on blood pressure and prevalence of hypertension was investigated in 377 consecutive subjects admitted to a sleep laboratory. Among patients, 124 (33%) had SA, 153 (41%) were obese, and 93 (25%) had systemic hypertension. Both oxygen desaturation (OD) and minimal oxygen saturation (Sa(O2min)) were related to BMI (p < 0.001) in patients without antihypertensive medication. Systolic and diastolic blood pressures were related to BMI and disease severity. Moreover, casual blood pressure, frequency of hypertension as well as OD and Sa(O2min)in were all significantly related to age. In a multivariate logistic regression analysis, age, BMI, and SA were all identified as independent predictors of hypertension. The relative risk associated with age was 4.3 (40 to 59 yr), with obesity 2.7 (greater than or equal to 27 kg/m(2)) and with SA 2.1 (> 30 desaturations/6 h). The relative risk for hypertension increased with increasing age and BMI. In SA, however, the relative risk was unchanged in patients with a higher number of desaturations (OD greater than or equal to 60, 2.2). Combined obesity and SA resulted in a 3.9 times increase in hypertension prevalence. We concluded that age, SA, and overweight represent both independent and additive risk factors for development of systemic hypertension.