Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature.
Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature.
复制标题
使用室温下保存长达六年的干血斑测定人类免疫缺陷病毒 1 型阳性婴儿的奈韦拉平耐药性。
DOI：
10.1128/jcm.00254-09
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发表时间：
2009
影响因子：
9.4
通讯作者：
Fiscus,SusanA
中科院分区：
文献类型：
--
作者：
Nelson,JulieAE;Loftis,AmyM;Kamwendo,Deborah;Fawzi,WafaieW;Taha,TahaE;Goldenberg,RobertL;Fiscus,SusanA
常温保存 3 至 6 年的干血斑会损失约 1 log10 的人类免疫缺陷病毒 1 型 (HIV-1) RNA，但大多数仍可进行耐药性基因分型。在 4 至 6 周时，7/16（43.5%）的 HIV-1 阳性 HIVNET 024 婴儿发现奈韦拉平耐药，但在其他时间点未发现耐药。
Dried blood spots that had been stored ambiently for 3 to 6 years lost approximately 1 log10of human immunodeficiency virus type 1 (HIV-1) RNA, but the majority could still be genotyped for resistance. Nevirapine resistance was found in 7/16 (43.5%) HIV-1-positive HIVNET 024 infants at 4 to 6 weeks, but no resistance was found at other time points.