The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.
The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.
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DOI：
10.1080/10409238.2017.1304353
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发表时间：
2017-06
影响因子：
6.5
通讯作者：
Buxton ILO
中科院分区：
文献类型：
--
作者：
Barnett SD;Buxton ILO
S亚硝基谷胱甘肽还原酶(GSNOR)是乙醇脱氢酶家族中的一种酶。与其他ADH酶相比，它的独特之处在于初级短链醇不是其主要底物。GSNOR代谢S-亚硝基谷胱甘肽(GSnO)、S-羟甲基谷胱甘肽(甲醛和谷胱甘肽的自发加合物)和一些醇。GSNOR通过催化GSNO的分解来调节细胞内反应性一氧化氮(·NO)的可获得性，并通过GSNO介导的蛋白质S亚硝化来间接调节RSNO。GSNOR的失调可以显著改变细胞内的稳态，从而导致疾病。GSNOR在平滑肌松弛、免疫功能、炎症、神经元发育和癌症进展等许多过程中发挥着重要的调节作用。近年来，GSNOR的治疗抑制作用被研究用于治疗哮喘、囊性纤维化和间质性肺疾病(ILD)。·NO对细胞通路的直接作用以及蛋白S亚硝化的重要调节作用与GSNOR的调节密切相关，并将其确定为一个重要的治疗靶点。
S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate. GSNOR metabolizes S-nitrosoglutathione (GSNO), S-hydroxymethylglutathione (the spontaneous adduct of formaldehyde and glutathione), and some alcohols. GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to disease. GSNOR plays an important regulatory role in smooth muscle relaxation, immune function, inflammation, neuronal development, and cancer progression, among many other processes. In recent years, the therapeutic inhibition of GSNOR has been investigated to treat asthma, cystic fibrosis and interstitial lung disease (ILD). The direct action of •NO on cellular pathways, as well as the important regulatory role of protein S-nitrosation, are closely tied to GSNOR regulation and define this enzyme as an important therapeutic target.
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影响因子：
7.7
作者：
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通讯作者：
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DOI：
10.1073/pnas.1113319109
发表时间：
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影响因子：
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DOI：
10.1124/jpet.110.171934
发表时间：
2010-10-10
影响因子：
3.5
作者：
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通讯作者：
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