RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.
RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.
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DOI：
10.1016/j.molcel.2009.08.002
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发表时间：
2009-08-28
期刊：
影响因子：
16
通讯作者：
Froedin, Morten
中科院分区：
文献类型：
--
作者：
Doehn, Ulrik;Hauge, Camilla;Frank, Scott R.;Jensen, Claus J.;Duda, Katarzyna;Nielsen, Jakob V.;Cohen, Michael S.;Johansen, Jens V.;Winther, Benny R.;Lund, Leif R.;Winther, Ole;Taunton, Jack;Hansen, Steen H.;Froedin, Morten
The RAS-stimulated RAF-MEK-ERK pathway confers epithelial cells with critical motile and invasive capacities during embryonic development, tissue regeneration and carcinoma progression. Yet many mechanisms by which ERK exerts this control remain elusive. Here, we demonstrate that the ERK-activated kinase RSK is necessary to induce motility and invasive capacities in non-transformed epithelial cells and carcinoma cells. RSK is moreover sufficient to induce certain motile responses. Expression profiling analysis revealed that a primary role of RSK is to induce transcription of potent pro-motile/invasive gene program by FRA1-dependent and independent mechanisms. Strikingly, the program enables RSK to coordinately modulate the extracellular environment, the intracellular motility apparatus, and receptors mediating communication between these compartments to stimulate motility and invasion. These findings uncover a general mechanism whereby the RAS-ERK pathway controls epithelial cell motility by identifying RSK as a key effector, from which emanates multiple highly coordinate transcription-dependent mechanisms for stimulation of motility and invasive properties.
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影响因子：
56.9
作者：
Cohen, MS;Zhang, C;Taunton, J
通讯作者：
Taunton, J
影响因子：
3.5
作者：
Shibazaki, Sekiya;Yu, Zhiheng;Somlo, Stefan
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Somlo, Stefan
影响因子：
11.4
作者：
Jung, Ki-Kyung;Liu, Xu-Wen;Kim, Hyeong-Reh Choi
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Kim, Hyeong-Reh Choi
影响因子：
11.2
作者：
Bellovin, DI;Bates, RC;Mercurio, AM
通讯作者：
Mercurio, AM
影响因子：
6.7
作者：
Dano, K;Behrendt, N;Romer, J
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Romer, J