COVID-19: Drug Targets and Potential Treatments
COVID-19: Drug Targets and Potential Treatments
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DOI：
10.1021/acs.jmedchem.0c00606
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发表时间：
2020-11-12
影响因子：
7.3
通讯作者：
Martinez, Ana
中科院分区：
文献类型：
--
作者：
Gil, Carmen;Ginex, Tiziana;Martinez, Ana
目前，人类正陷入由新出现的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的大流行，威胁着全球公共卫生。到目前为止，还没有药物或疫苗被批准用于治疗这种冠状病毒COVID-19引起的严重疾病。在本文中，我们将重点关注主要的基于病毒和基于宿主的靶点，这些靶点可以指导药物化学的努力，以发现治疗这种毁灭性疾病的新药。原则上，所有参与病毒复制和控制宿主细胞机制的CoV酶和蛋白质都是寻找SARS-CoV-2治疗方案的潜在药物靶点。该观点从结构的角度概述了主要靶标，以及报道的对SARS-CoV-2和/或其他CoV具有活性的治疗化合物。此外，先天免疫反应对冠状病毒感染的作用和相关的治疗方案将被提出。
Currently, humans are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health worldwide. To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devastating disease. In principle, all CoV enzymes and proteins involved in viral replication and the control of host cellular machineries are potentially druggable targets in the search for therapeutic options for SARS-CoV-2. This Perspective provides an overview of the main targets from a structural point of view, together with reported therapeutic compounds with activity against SARS-CoV-2 and/or other CoVs. Also, the role of innate immune response to coronavirus infection and the related therapeutic options will be presented.