Using autologous intrauterine platelet-rich plasma to improve the reproductive outcomes of women with recurrent implantation failure
Using autologous intrauterine platelet-rich plasma to improve the reproductive outcomes of women with recurrent implantation failure
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DOI：
10.5935/1518-0557.20190055
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发表时间：
2020-01-01
影响因子：
1.5
通讯作者：
Golsorkhtabaramiri, Masoumeh
中科院分区：
文献类型：
--
作者：
Aghajanzadeh, Fateme;Esmaeilzadeh, Sedighe;Golsorkhtabaramiri, Masoumeh
目的：生殖科临床经常遇到反复着床失败（RIF）的病例。本研究评估了富血小板血浆（PRP）是否可能改善RIF患者的植入结局。方法：30例接受冷冻解冻胚胎移植的RIF患者被纳入本研究。在胚胎移植前48小时给予自体纯化血小板制剂的宫内输注。在种植，临床妊娠，流产率周期与不PRP infusations.Results：在PRP组的种植率为6.7%的周期进行了分析。在植入、临床妊娠、持续妊娠和流产率方面，使用和不使用PRP输注的冻融胚胎移植无显著差异。然而，PRP输注（科恩的d=0.39）对植入率的影响大小揭示了中等strength.Conclusion的关系：富血小板血浆可能会产生潜在的有益效果，作为一种安全的治疗选择，提供了与其他治疗方法，旨在改善反复植入失败的妇女的生殖结果。
Objective: Reproductive clinics are often faced with cases of repeated implantation failure (RIF). This study evaluated whether platelet-rich plasma (PRP) might improve the implantation outcomes of patients suffering from RIF.Methods: Thirty women with RIF submitted to frozen-thawed embryo transfers were included in the study. Intrauterine infusions of autologous purified platelet preparations were administered 48 hours prior to embryo transfer. Differences in implantation, clinical pregnancy, and miscarriage rates of cycles with and without PRP infusions were analyzed.Results: The implantation rate seen in the PRP group was 6.7%. No significant difference was found the between the implantation, clinical pregnancy, ongoing pregnancy, and miscarriage rates of frozen-thawed embryo transfers with and without PRP infusion. However, the effect size of PRP infusion (Cohen's d=0.39) on implantation rates revealed a relationship in medium strength.Conclusion: Platelet-rich plasma might potentially yield beneficial effects as a safe therapeutic option offered alongside other treatments designed to improve the reproductive outcomes of women with repeated implantation failure.