Resting-state networks in the macaque at 7 T
Resting-state networks in the macaque at 7 T
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DOI：
10.1016/j.neuroimage.2011.02.063
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Everling, Stefan
中科院分区：
文献类型：
--
作者：
Hutchison, R. Matthew;Leung, L. Stan;Everling, Stefan
组织在多种疾病状态下发生改变，提示其可作为诊断或预后指标。进一步研究大规模脑网络的潜在机制、组织和改变需要一个同源的动物模型，以允许神经生理学记录和实验操作。目前的研究提出了一种综合评估猕猴静息状态网络基于评估内在低频波动的血氧水平依赖的信号使用组独立分量分析。在感觉、运动和认知处理的多个层次上发现了网络。结果表明，猕猴与人类具有显著的同源网络组织，从而为其作为研究正常和异常脑连接的动物模型提供了强有力的支持，并有助于在大规模脑网络背景下解释电生理记录。(C) 2011爱思唯尔公司版权所有。
organization are altered in multiple disease states suggesting their use as diagnostic or prognostic indicators. Further investigation into the underlying mechanisms, organization, and alteration of large-scale brain networks requires a homologous animal model that would allow neurophysiological recordings and experimental manipulations. The current study presents a comprehensive assessment of macaque resting-state networks based on evaluation of intrinsic low-frequency fluctuations of the blood oxygen-level-dependent signal using group independent component analysis. Networks were found underlying multiple levels of sensory, motor, and cognitive processing. The results demonstrate that macaques share remarkable homologous network organization with humans, thereby providing strong support for their use as an animal model in the study of normal and abnormal brain connectivity as well as aiding the interpretation of electrophysiological recordings within the context of large-scale brain networks. (C) 2011 Elsevier Inc. All rights reserved.