Influence on retrolental fibroplasia of intramuscular vitamin E administration during respiratory distress syndrome.
Influence on retrolental fibroplasia of intramuscular vitamin E administration during respiratory distress syndrome.
复制标题
呼吸窘迫综合征期间肌肉注射维生素E对晶状体后纤维增生的影响。
DOI：
10.1016/s0161-6420(82)34830-7
复制
发表时间：
1982
期刊：
影响因子：
13.7
通讯作者：
Ehrenkranz,RA
中科院分区：
文献类型：
--
作者：
Puklin,JE;Simon,RM;Ehrenkranz,RA
在一项随机双盲研究中，评价了在呼吸窘迫综合征（RDS）治疗急性期给予维生素E对早产儿视网膜病变（ROP）发展的影响。100名新生儿分别在出生后24小时内、24小时、48小时和168小时肌肉注射维生素E或安慰剂。当婴儿保持在富氧环境中并且不能耐受喂养和维生素补充剂时，每周给予额外剂量两次。与安慰剂治疗的婴儿相比，肠外维生素E治疗的婴儿血清维生素E水平显著升高。由于维生素E的营养来源，大多数安慰剂治疗的患者在出生后第二周达到正常的血清维生素E水平。两组婴儿的RDS严重程度相似。74名婴儿，37名维生素E治疗，37名安慰剂治疗，存活超过10天，并进行眼科检查。其中17例患者的I期和II期ROP发生了积极变化; 9例（24.3%）维生素E治疗患者和8例（21.6%）安慰剂治疗患者（P= 0.572）。没有婴儿出现严重的瘢痕变化，他们的视网膜发现消退。与ROP发展相关的危险因素的发生率在维生素E治疗和安慰剂治疗的婴儿中同样发生。因此，与标准新生儿护理（包括每日口服维生素E补充剂）相比，本研究中描述的维生素E给药并未导致ROP活动期发生率进一步降低。
The effect of vitamin E administered during the acute phase of therapy for respiratory distress syndrome (RDS) on the development of retinopathy of prematurity (ROP) was evaluated in a randomized double-masked study. One hundred neonates received either vitamin E or placebo intramuscularly within the first 24 hours of birth and at 24, 48, and 168 hours respectively. Additional doses were given twice weekly while the infant remained in an oxygen-enriched environment and could not tolerate feedings and vitamin supplements. Parenteral vitamin Etreated infants had significantly increased serum vitamin E levels compared to placebo-treated infants. Most placebo-treated patients attained normal serum vitamin E levels during the second week of life because of nutritional sources of vitamin E. Infants in both groups had RDS of similar severity. Seventy-four infants, 37 vitamin E-treated and 37 placebotreated, survived longer than 10 days and had ophthalmologic examinations. Active changes of Stage I and Stage II ROP were noted in 17 of those patients; 9 (24.3%) vitamin E-treated and 8 (21.6%) placebotreated patients (P= 0.572). No infants developed severe cicatricial changes, and their retinal findings regressed. The incidence of risk factors associated with ROP development occurred equally in the vitamin E-treated and placebo-treated infants that developed ROB. Thus, vitamin E administration as described in this study did not result in any further reduction in the incidence of the active stages of ROP over that seen with standard neonatal care, which included daily oral Vitamin E supplements.