'Life is a highway': membrane trafficking during cytokinesis.
'Life is a highway': membrane trafficking during cytokinesis.
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DOI：
10.1111/j.1600-0854.2010.01139.x
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Burgess DR
中科院分区：
文献类型：
--
作者：
McKay HF;Burgess DR
细胞质分裂是细胞周期的最后阶段，是形成两个有活力的子细胞的重要步骤。近年来，膜运输已被证明是重要的完成细胞质分裂。起源于内吞和分泌途径的囊泡被穿梭到进入卵裂沟的质膜上，将膜和蛋白质运送到这个动态区域。细胞成像的进步导致了关于活细胞中囊泡运动的令人兴奋的新发现。最近的研究揭示了在动物细胞胞质分裂过程中，由调节蛋白控制的膜运输的重要作用。胞质分裂过程中，胞吞和分泌途径以及运动蛋白在将囊泡运送到卵裂沟中是必不可少的。
Cytokinesis, the final stage of the cell cycle, is an essential step toward the formation of two viable daughter cells. In recent years, membrane trafficking has been shown to be important for the completion of cytokinesis. Vesicles originating from both the endocytic and secretory pathways are known to be shuttled to the plasma membrane of the ingressing cleavage furrow, delivering membrane and proteins to this dynamic region. Advances in cell imaging have led to exciting new discoveries regarding vesicle movement in living cells. Recent work has revealed a significant role for membrane trafficking, as controlled by regulatory proteins, during cytokinesis in animal cells. The endocytic and secretory pathways as well as motor proteins are revealed to be essential in the delivery of vesicles to the cleavage furrow during cytokinesis.
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