Early infant feeding effect on growth and body composition during the first 6 years and neurodevelopment at age 72 months
Early infant feeding effect on growth and body composition during the first 6 years and neurodevelopment at age 72 months
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DOI：
10.1038/s41390-020-01157-z
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发表时间：
2020-09-22
影响因子：
3.6
通讯作者：
Andres，Aline
中科院分区：
文献类型：
--
作者：
Sobik，Sarah;Sims，Clark R.;Andres，Aline
背景本研究纵向描述了母乳喂养儿童的发育状况、生长和身体组成（母乳喂养的，BF）、基于牛奶（MF）或基于大豆蛋白（SF）的婴儿配方食品从3至12个月。48、60和72个月（NCT 00616395）。学龄前语言量表-3，儿童记忆量表指数（CMS），和韦氏学前和小学智力量表在72个月大时进行管理。混合效应模型调整胎龄，出生体重，儿童种族和性别，父母的教育程度，和母亲的智商进行了performed.ResultsBody Mass Index（BMI）显着降低BF儿童24和72个月之间相比，SF儿童。在3个月和6个月时，BF婴儿的脂肪量（FM）显著高于SF婴儿，而BF儿童在36个月和48个月时的FM显著低于SF儿童。SF参与者的CMS延迟识别指数高于MF参与者（p= 0.009）。There was no other significant difference in developmental outcomes between groups. Conclusions总之，BF，MF，和SF支持足够的生长和发育，直到6岁。ImpactAlthough soybean protein-based infant formula is reported to support normal infant growth and development compared to cow's milk-based formula and human milk，关于这些喂养方法对学龄儿童的影响的数据有限。这项研究表明，在身体成分，特别是BMI，24个月后，在生命的第一年和幼儿期，两种婴儿喂养方法之间的差距很大;然而，所有饮食都提供足够的营养，以维持正常发育，直至72个月。
BackgroundThis study longitudinally characterized the developmental status, growth, and body composition of children who were fed human milk (breastfed, BF), cow’s milk-based (MF), or soy protein-based (SF) infant formula from 3 to 12 months.MethodsStandardized anthropometrics and dual-energy X-ray absorptiometry were used to characterize growth and body composition at 3, 6, 9, 12, 24, 36, 48, 60, and 72 months (NCT00616395). Preschool Language Scale-3, Children’s Memory Scale Index (CMS), and Wechsler Preschool and Primary Scale of Intelligence were administered at age 72 months. Mixed-effects models adjusting for gestational age, birth weight, child race and sex, parental education, and maternal IQ were performed.ResultsBody Mass index (BMI) was significantly lower between 24 and 72 months in BF children compared to SF children. At 3 and 6 months, BF infants had significantly higher fat mass (FM) than SF infants, whereas BF children had significantly lower FM at 36 and 48 months than SF children. Delayed Recognition Index of the CMS was higher for SF than for MF participants (p= 0.009). There was no other significant difference in developmental outcomes between groups.ConclusionsIn conclusion, BF, MF, and SF support adequate growth and development up to age 6 years.ImpactAlthough soy protein-based infant formula is reported to support normal infant growth and development compared to cow’s milk-based formula and human milk, there are limited data on the effect of these feeding methods in school-aged children.This study suggests a significant difference in body composition, specifically BMI, after 24 months between infant feeding methods during the first year of life and in early childhood; however, all diets provide adequate nutrients to maintain normal development up to 72 months.