An event-related potential study of attention and recognition memory in infants with iron deficiency anemia
An event-related potential study of attention and recognition memory in infants with iron deficiency anemia
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DOI：
10.1542/peds.2006-2525
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发表时间：
2007-08-01
期刊：
影响因子：
8
通讯作者：
Jacobson, Joseph L.
中科院分区：
文献类型：
--
作者：
Burden, Matthew J.;Westerlund, Alissa J.;Jacobson, Joseph L.
目标.这项工作的目的是确定是否缺铁性贫血在婴儿期代表缺陷的危险因素，在注意力和记忆力的发展，使用事件相关电位。在9个月和/或12个月时，从15名缺铁性贫血婴儿和19名铁充足的婴儿中获得了无人为因素的事件相关电位数据，以测试婴儿区分高度熟悉的刺激（母亲的脸）和陌生人的脸的能力。在缺铁性贫血和铁充足组的两个年龄段，均发现了与注意力相关的中潜伏期负成分和与记忆更新相关的迟发性正慢波。与9个月时的年龄适当的发展模式相一致，铁充足组对母亲表现出更大的注意力反应（负成分），对陌生人表现出更大的记忆更新（正慢波）。这种反应模式在缺铁性贫血组中直到12个月才明显，表明认知发育延迟。这些数据表明，缺铁性贫血不利地影响分配的神经生理资源的注意力和识别记忆在处理熟悉和不熟悉的刺激的信息。这种认知发育的延迟可能反映了中枢神经系统功能效率的改变，这些功能似乎与早期缺铁有关。
Objectives. The purpose of this work was to determine whether iron-deficiency anemia in infancy represents a risk factor for deficits in attention and memory development using event-related potentials.Methods. Artifact-free event-related potential data were obtained at 9 and/or 12 months from 15 infants with iron-deficiency anemia and 19 who were iron sufficient during a test of the infant's ability to discriminate a highly familiar stimulus, the mother's face, from a stranger's face.Results. A midlatency negative component associated with attention and a late-occurring positive slow wave associated with memory updating were identified at both ages in the iron-deficiency anemia and iron-sufficient groups. Consistent with the age-appropriate pattern of development at 9 months, the iron-sufficient group showed a greater attentional response (negative component) to the mother and a greater updating of memory for the stranger (positive slow wave). This pattern of responses was not evident in the iron-deficiency anemia group until 12 months, suggesting a delay in cognitive development.Conclusions. These data suggest that iron-deficiency anemia adversely affects the allocation of neurophysiologic resources to attention and recognition memory during the processing of information about familiar and unfamiliar stimuli. This delay in cognitive development may reflect alterations in efficiency of central nervous system functions that seem related to early iron deficiency.