Dietary fats and inflammation: The medicinal use of fish oil
Dietary fats and inflammation: The medicinal use of fish oil
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DOI：
10.1111/j.1747-0080.2008.01310.x
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发表时间：
2009-03-01
影响因子：
3.1
通讯作者：
Proudman, Susanna M.
中科院分区：
文献类型：
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作者：
Cleland, Leslie G.;James, Michael J.;Proudman, Susanna M.
在本期的评论中，Clifton 调查了源自花生四烯酸 (C20: 4 omega-6) 的氧脂质信使（omega-6 类二十烷酸），以及长链 omega-3 脂肪酸二十碳五烯酸（C20: 5 omega-3，EPA）和二十二碳六烯酸（C22: 6 omega-3，EPA）抑制其合成和作用的可能性。 DHA），存在于鱼油中。关于关节炎引起的关节疼痛，需要重点解释 omega-6 类二十烷酸、前列腺素 E2 (PGE2)。这种介质会增加对疼痛（伤害感受）的敏感性，这种疼痛可能是关节炎关节运动过程中的拉伸和压力引起的。 NSAIDs（也称为“cyclo-oxygense-2 抑制剂”）的镇痛作用归因于 PGE2 合成的减少。 4 PGE2 合成在体外受到 EPA 和 DHA 的抑制，其效力与某些 NSAID 相似。 5 富含 EPA 和 DHA 的膳食鱼油已被证明可以抑制离体 PGE2 的合成，6 并减少其他炎症类二十烷酸和细胞因子的合成。 3 鉴于这些代谢效应，富含 EPA 和 DHA 的鱼油的药用已被证明可以减轻类风湿关节炎 6 和系统性狼疮的症状并改善疾病控制，这并不奇怪。 7
In a review in this issue, Clifton provides a survey of the oxy-lipids messengers (omega-6 eicosanoids) derived from arachidonic acid (C20: 4 omega-6) and possibilities for inhibition of their synthesis and actions by the long-chain omega-3 fatty acids eicosapentaenoic acid (C20: 5 omega-3, EPA) and docosahexaenoic acid (C22: 6 omega-3, DHA), which are present in fish oil. With regard to joint pain in arthritis, the omega-6 eicosanoid, prostaglandin E2 (PGE2), warrants explanatory emphasis. This mediator increases sensitivity to pain (nociception), which can arise from stretch and pressure during movement of arthritic joints. The analgesic effect of NSAIDs, also known as ‘cyclo-oxygense-2 inhibitors’, is attributed to reduced synthesis of PGE2. 4 PGE2 synthesis is inhibited by EPA and DHA in vitro with a similar potency to some NSAIDs. 5 Dietary fish oil rich in EPA and DHA has been shown to inhibit synthesis of PGE2 ex vivo, 6 as well as reduce synthesis of other inflammatory eicosanoids and cytokines. 3 In view of these metabolic effects, it is not surprising that medicinal use of fish oil, which is rich in EPA and DHA, has been shown to reduce symptoms and improve disease control in rheumatoid arthritis6 and systemic lupus. 7