Number of tumor foci as predictor of lateral lymph node metastasis in papillary thyroid carcinoma
Number of tumor foci as predictor of lateral lymph node metastasis in papillary thyroid carcinoma
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DOI：
10.1002/hed.23650
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发表时间：
2015-05-01
影响因子：
2.9
通讯作者：
Chung, Jae Hoon
中科院分区：
文献类型：
--
作者：
Kim, Hye Jeong;Park, Hyeong Kyu;Chung, Jae Hoon
背景本研究的目的是通过肿瘤灶的数量来确定甲状腺乳头状癌（PTC）患者的临床病理特征。方法对2095例甲状腺乳头状癌患者进行回顾性分析。根据肿瘤灶的数量将研究人群分为 4 组：N1（1 个肿瘤灶）、N2（2 个灶）、N3（3 个灶）和 N4（4 个或更多灶）。结果肿瘤灶数量的增加与诊断时年龄较大 (p = .006)、颈部淋巴结转移 (p < .001) 和初次手术时疾病的晚期 TNM 分期 (p = .001) 显着相关。与 N1 组相比，N2、N3 和 N4 组外侧淋巴结转移的多变量调整比值比 (OR) 和 95% 置信区间 (95% CI) 分别为 OR 1.53 (95% CI, 1.05-2.22)、OR 2.57 (95% CI, 1.50-4.42) 和 OR 2.88 (95% CI, 1.50-4.42)。分别为1.42-5.84)。结论肿瘤灶数量的增加与诊断时年龄较大、颈部淋巴结转移和PTC晚期TNM分期密切相关。肿瘤灶的数量独立预测侧淋巴结转移。 (c) 2014 年 Wiley 期刊公司 Head Neck37: 650-654, 2015
BackgroundThe purpose of this study was to determine the clinicopathologic characteristics of patients with papillary thyroid carcinoma (PTC) by the number of tumor foci.MethodsA retrospective analysis of 2095 patients with PTC was performed. The study population was divided into 4 groups based on the number of tumor foci: N1 (1 tumor focus), N2 (2 foci), N3 (3 foci), and N4 (4 or more foci).ResultsAn increasing number of tumor foci was significantly associated with older age at diagnosis (p = .006), cervical lymph node metastasis (p < .001), and advanced TNM stage of disease (p = .001) at initial surgery. The multivariate adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the N2, N3, and N4 groups compared to the N1 group for lateral lymph node metastasis were OR 1.53 (95% CI, 1.05-2.22), OR 2.57 (95% CI, 1.50-4.42), and OR 2.88 (95% CI, 1.42-5.84), respectively.ConclusionAn increase in the number of tumor foci was strongly associated with older age at diagnosis, cervical lymph node metastasis, and advanced TNM stage of PTC. The number of tumor foci independently predicted lateral lymph node metastasis. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 650-654, 2015