Dilated Cardiomyopathy Risk in Patients with Coronavirus Disease 2019: How to Identify and Characterise it Early?
Dilated Cardiomyopathy Risk in Patients with Coronavirus Disease 2019: How to Identify and Characterise it Early?
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DOI：
10.15420/ecr.2020.17
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
Matsumori, Akira
中科院分区：
文献类型：
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作者：
Komiyama, Maki;Hasegawa, Koji;Matsumori, Akira
多项证据表明，血肌钙蛋白升高与 2019 年新型冠状病毒病 (COVID-19) 患者的不良预后密切相关。 COVID-19造成心肌损伤的可能机制包括循环和呼吸衰竭导致的缺血、凝血能力增加导致的心外膜或心肌内小冠状动脉血栓性阻塞，以及全身炎症或病毒与其受体血管紧张素转换酶2（ACE2）直接结合引起的心肌炎，血管紧张素转换酶2在心脏中大量表达。据推测，病毒感染后持续的免疫激活会增加 COVID-19 患者患扩张型心肌病的风险。
Multiple lines of evidence have shown that elevated blood troponin is strongly associated with poor prognosis in patients with the novel coronavirus disease 2019 (COVID-19). Possible mechanisms of myocardial injury in COVID-19 include ischaemia due to circulatory and respiratory failure, epicardial or intramyocardial small coronary artery thrombotic obstruction due to increased coagulability, and myocarditis caused by systemic inflammation or direct binding of the virus to its receptor, angiotensin-converting enzyme-2 (ACE2), which is abundantly expressed in the heart. It is postulated that persistent immune activation upon viral infection increases the risk of developing dilated cardiomyopathy in COVID-19 patients.