ENKEPHALIN MAY MEDIATE EUPHORIA AND DRIVE-REDUCTION REWARD
ENKEPHALIN MAY MEDIATE EUPHORIA AND DRIVE-REDUCTION REWARD
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DOI：
10.1038/266556a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
STEIN, L
中科院分区：
文献类型：
--
作者：
BELLUZZI, JD;STEIN, L
在大脑中发现阿片受体1和吗啡样五肽（甲硫氨酸-脑啡肽和亮氨酸-脑啡肽）2，这表明脑啡肽受体可能是阿片类药物诱导镇痛和欣快的部位，脑啡肽本身可能是大脑系统中调节疼痛和愉悦的递质或调节剂3 -6。对动物的观察表明，适当的脑啡肽中枢给药可产生吗啡样成瘾7 - 9和身体依赖性10。我们在这里报告说，脑啡肽也可能具有吗啡的兴奋或奖励特性，因为大鼠将脑啡肽注射直接输送到自己的脑室11。特别令人感兴趣的是，鉴于甲硫氨酸肽的一般上级效力2、8、9，观察到亮氨酸脑啡肽比甲硫氨酸脑啡肽具有更大的亲合力。
THE identification in brain of opiate receptors1and morphine-like pentapeptides (methionine-enkephalin and leucine-enkephalin)2has led to suggestions that enkephalin receptors may be sites at which opiate drugs induce analgesia and euphoria, and that the enkephalins themselves may be transmitters or modulators in brain systems for the regulation of pain and pleasure3–6. Observations in animals reveal that appropriate central administration of enkephalin produces morphine-like analgesia7–9and physical dependence10. We report here that enkephalin also may share the euphorigenic or rewarding properties of morphine in that rats will work for enkephalin injections delivered directly into the ventricles of their own brains11. Of particular interest, in the light of the generally superior potency of the methionine peptide2,8,9, is the observation that leucine-enkephalin is self-administered with greater avidity than methionine-enkephalin.