Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia
Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia
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DOI：
10.1097/00000542-200003000-00016
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发表时间：
2000-03-01
期刊：
影响因子：
8.8
通讯作者：
Hoeft, A
中科院分区：
文献类型：
--
作者：
Bruhn, J;Röpcke, H;Hoeft, A
作者假设高麻醉浓度时的脑电图比低麻醉浓度时表现出更多的“有序”和更少的“随机性”。“近似熵”是由Kolmogorov-Sinai熵公式导出的一个新的统计参数，用来量化数据的规律性。近似熵基于对前一个振幅值的了解，量化了脑电图后续振幅值的可预测性。研究地氟醚麻醉时脑电近似熵与谱边频率95、中位数频率和双谱指数的剂量-反应关系。方法：对12例妇科剖腹手术患者进行研究。在打开和关闭腹膜期间，地氟醚潮汐末浓度在0.5 - 1.6最小肺泡浓度（MAC）之间变化。测定脑电图近似熵、脑电图中位数频率、频谱边缘频率95和双谱指数，并比较各指标对地氟醚效应室浓度的预测效果。结果：脑电图近似熵在观察地氟醚浓度范围内持续下降。近似熵（预测概率P-K = 0.86 +/- 0.06）作为地氟醚浓度指标的性能与谱边频率95 （P-K = 0.86 +/- 0.06）和双谱指数（P-K = 0.82 +/- 0.06）相似，且在统计学上显著优于中位数频率（P-K = 0.78 +/- 0.06）。结论：随着地氟醚浓度的增加，脑电图的规律性程度增加。近似熵可以作为麻醉药物作用的一种有用的脑电测量方法。
Background The authors hypothesized that the electroencephalogram (EEG) during higher anesthetic concentrations would show more "order" and less "randomness" than at lower anesthetic concentrations. "Approximate entropy" is a new statistical parameter derived from the Kolmogorov-Sinai entropy formula which quantifies the amount of regularity in data. The approximate entropy quantifies the predictability of subsequent amplitude values of the EEG based on the knowledge of the previous amplitude values. The authors investigated the dose-response relation of the EEG approximate entropy during desflurane anesthesia in comparison with spectral edge frequency 95, median frequency, and bispectral index.Methods: Twelve female patients were studied during gynecologic laparotomies. Between opening and closure of the peritoneum, end-tidal desflurane concentrations were varied between 0.5 and 1.6 minimum alveolar concentration (MAC). The EEG approximate entropy, median EEG frequency, spectral edge frequency 95, and bispectral index were determined and the performance of each to predict the desflurane effect compartment concentration, obtained by simultaneous pharmacokinetic-pharmacodynamic modeling, was compared,Results: Electroencephalogram approximate entropy decreased continuously over the observed concentration range of desflurane. The performance of the approximate entropy (prediction probability P-K = 0.86 +/- 0.06) as an indicator for desflurane concentrations is similar to spectral edge frequency 95 (P-K = 0.86 +/- 0.06) and bispectral index (P-K = 0.82 +/- 0.06) and is statistically significantly better than median frequency (P-K = 0.78 +/- 0.06).Conclusions: The amount of regularity in the EEG increases with increasing desflurane concentrations. The approximate entropy could be a useful EEG measure of anesthetic drug effect.