Printable microscale interfaces for long-term peripheral nerve mapping and precision control.
Printable microscale interfaces for long-term peripheral nerve mapping and precision control.
复制标题
可打印的微型接口，用于长期周围神经测绘和精确控制。
DOI：
10.1038/s41467-020-18032-4
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发表时间：
2020
影响因子：
16.6
通讯作者：
Gardner,TimothyJ
中科院分区：
文献类型：
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作者：
Otchy,TimothyM;Michas,Christos;Lee,Blaire;Gopalan,Krithi;Nerurkar,Vidisha;Gleick,Jeremy;Semu,Dawit;Darkwa,Louis;Holinski,BradleyJ;Chew,DanielJ;White,AliceE;Gardner,TimothyJ
生物电子医学的新兴领域寻求解码和调节外周神经系统信号，以获得对靶向终末器官和效应器的治疗控制。目前的方法严重依赖于基于电极的设备，但是尺寸可扩展性、材料和微制造挑战、有限的手术可及性以及生物力学动态植入环境是开发和部署外围接口技术的重大障碍。在这里，我们提出了一种微型植入式设备-nanoclip-在小动物模型，开始满足这些限制的慢性接口与细外周神经。我们证明了在多周的时间尺度上对行为相关神经活动进行稳定，高信噪比记录的能力。此外，我们表明，多通道，电流舵为基础的刺激范围内的小设备可以实现多维控制的小神经。这些结果突出了新的微尺度设计和制造技术的潜力，实现可行的设备，长期的外围接口。
The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying peripheral interfacing technologies. Here, we present a microscale implantable device – the nanoclip – for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints. We demonstrate the capability to make stable, high signal-to-noise ratio recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation within the confines of the small device can achieve multi-dimensional control of a small nerve. These results highlight the potential of new microscale design and fabrication techniques for realizing viable devices for long-term peripheral interfacing.