The biology of PECAM-1
The biology of PECAM-1
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DOI：
10.1172/jci119129
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发表时间：
1997-01-01
影响因子：
15.9
通讯作者：
Newman, PJ
中科院分区：
文献类型：
--
作者：
Newman, PJ
血小板内皮细胞粘附分子-1 (PECAM-1) 是免疫球蛋白 (Ig) 超家族的 130 kD 成员，在循环血小板、单核细胞、中性粒细胞和选定的 T 细胞亚群的表面表达。它也是内皮细胞细胞间连接处的主要成分 (1-3)，其中聚集了多达 106 个 PECAM-1 分子 (4)。除少数例外，PECAM-1 不存在于成纤维细胞、上皮细胞、肌肉或其他非血管细胞上。自从近 10 年前 (5, 6) 被克隆以来，人们对这种细胞粘附受体的结构及其在血管细胞中的功能有了很多了解。这篇简短的观点的目的是回顾 PECAM-1 生物学领域的进展，并让读者了解有关以下方面的最新概念：(a) PECAM-1 在表达它的不同血管细胞中的功能；(b) PECAM-1 介导细胞间相互作用的分子机制；(b) PECAM-1 介导细胞间相互作用的分子机制； (c)其在双向跨膜信号转导中的作用。为了符合本系列讨论人类生物学和病理生理学背景下的细胞粘附问题的目的，PECAM-1介导的细胞相互作用与血栓形成、炎症和免疫疾病的潜在临床相关性将在整个综述的相关点上得到强调。
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and selected T cell subsets. It is also a major constituent of the endothelial cell intercellular junction (1–3), where up to 106 PECAM-1 molecules (4) are concentrated. With a few minor exceptions, PECAM-1 is not present on fibroblasts, epithelium, muscle, or other nonvascular cells. Since its cloning nearly 10 yr ago (5, 6), much has been learned about the structure of this cell adhesion receptor and its function in vascular cells. The purpose of this brief Perspective is to review progress in the field of PECAM-1 biology, and to bring the reader up to date on current concepts about (a) the function of PECAM-1 in the different vascular cells in which it is expressed;(b) the molecular mechanisms by which PECAM-1 mediates cell–cell interactions; and (c) its role in bidirectional transmembrane signal transduction. In keeping with the intent of this series to discuss issues of cell adhesion in the context of human biology and pathophysiology, the potential clinical relevance of PECAM-1–mediated cellular interactions to thrombotic, inflammatory, and immunological diseases will be underscored at relevant points throughout the review.