Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease
Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease
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DOI：
10.1016/j.mvr.2012.06.011
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发表时间：
2012-11-01
影响因子：
3.1
通讯作者：
Kato, Gregory J.
中科院分区：
文献类型：
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作者：
Gorbach, Alexander M.;Ackerman, Hans C.;Kato, Gregory J.
血管功能障碍是镰状细胞病（SCD）的重要病理生理表现，这种疾病会增加肺动脉高压和中风的风险。我们假设红外 (IR) 成像可以检测反映血管功能的皮肤血流变化。我们对 25 名患有 SCD 的成年人进行了红外成像和常规应变计体积描记术，这些成人在基线时以及在动脉内输注内皮依赖性血管舒张剂乙酰胆碱 (ACh)、内皮非依赖性血管舒张剂硝普钠 (SNP) 和 NOS 抑制剂 L-NMMA 期间进行了红外成像和常规应变计体积描记。通过红外成像测量的皮肤温度以剂量依赖性方式增加，以分级注射乙酰胆碱（+1.1 摄氏度，p
Vascular dysfunction is an important pathophysiologic manifestation of sickle cell disease (SCD), a condition that increases risk of pulmonary hypertension and stroke. We hypothesized that infrared (IR) imaging would detect changes in cutaneous bloodflow reflective of vascular function. We performed IR imaging and conventional strain gauge plethysmography in twenty-five adults with SCD at baseline and during intra-arterial infusions of an endothelium-dependent vasodilator acetylcholine (ACh), an endothelium-independent vasodilator sodium nitroprusside (SNP), and a NOS inhibitor L-NMMA. Skin temperature measured by IR imaging increased in a dose-dependent manner to graded infusions of ACh (+1.1 degrees C, p