The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression.
The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression.
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黑色素瘤的进化 - 超越遗传进展的二元模型。
DOI：
10.1016/j.jid.2019.08.002
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Shain,AHunter
中科院分区：
文献类型：
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作者：
Zeng,Hanlin;Judson-Torres,RobertL;Shain,AHunter
到目前为止，已经对1000多种黑素细胞肿瘤进行了测序，涵盖了肿瘤发生的各个阶段，为它们的基因组学景观提供了详细的视图。这与基因工程技术的进步相吻合，这些技术使分子生物学家能够极其精确地编辑人类基因组，并建立新的小鼠模型来模拟疾病的进展。在这篇综述中，我们描述了如何利用这些技术以前所未有的分辨率提供对黑色素瘤演变的见解，揭示了黑色素瘤演变的先前模型，其中通路在黑色素瘤的形成过程中以二元方式打开或关闭，过于简化。
To date, over 1000 melanocytic neoplasms, spanning all stages of tumorigenesis, have been sequenced, offering detailed views into their -omic landscapes. This has coincided with advances in genetic engineering technologies that allow molecular biologists to edit the human genome with extreme precision and new mouse models to simulate disease progression. In this review, we describe how these technologies are being harnessed to provide insights into the evolution of melanoma at an unprecedented resolution, revealing that prior models of melanoma evolution, in which pathways are turned ‘on’ or ‘off’ in a binary fashion during the run-up to melanoma, are oversimplified.