Interacting Partners of AMPA-Type Glutamate Receptors
Interacting Partners of AMPA-Type Glutamate Receptors
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AMPA 型谷氨酸受体的相互作用伙伴
DOI：
10.1007/s12031-012-9724-6
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发表时间：
2012-10-01
影响因子：
3.1
通讯作者：
Zhang, Chen
中科院分区：
文献类型：
--
作者：
Cheng, Juan;Dong, Jie;Zhang, Chen
谷氨酸是大脑中主要的兴奋性神经递质。α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic，AMPA）受体是一种内源性离子型谷氨酸受体，介导哺乳动物脑内信息加工和整合所必需的快速兴奋性突触传递。AMPA受体的修饰被认为是学习和记忆的分子基础，AMPA受体的损伤导致某些神经系统疾病，包括癫痫、自闭症谱系障碍和阿尔茨海默病。因此，已经进行了广泛的研究，并且这些研究揭示了控制神经元中AMPA受体的表达、运输和功能的复杂蛋白质-蛋白质网络。在这里，我们总结了AMPA型谷氨酸受体的相互作用伙伴和这些相互作用的功能意义。
Glutamate is the principal excitatory neurotransmitter in the brain. The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic (AMPA) receptors, as one of several types of endogenous ionotropic glutamate receptors, mediate the fast excitatory synaptic transmission that is essential for information processing and integration in the mammalian brain. Modifications of AMPA receptors are assumed to be the molecular basis underlying learning and memory, and impairments of AMPA receptors cause certain neurological diseases, including epilepsy, autism spectrum disorders, and Alzheimer's disease. Thus, extensive studies have been conducted, and these have revealed a complex protein–protein network controlling the expression, trafficking, and function of AMPA receptors in neurons. Here, we summarize the interacting partners of AMPA-type glutamate receptors and the functional implications of these interactions.