Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
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DOI：
10.1038/s41598-018-32767-7
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发表时间：
2018-09-28
影响因子：
4.6
通讯作者：
Seoane, Luisa M.
中科院分区：
文献类型：
--
作者：
Folgueira, Cintia;Barja-Fernandez, Silvia;Seoane, Luisa M.
尿鸟苷素是一种16个氨基酸的肽，其构成肠-脑轴的关键组分，与体重调节特别相关。在儿童期和青春期，有显著代谢变化的生命时期;存在有限的数据，在青春期测量尿鸟苷素原，但在青春期前儿童中没有。本研究探讨了肥胖儿童尿鸟苷素原循环水平及其与肥胖、性别和青春期发育的关系。我们分析了117名儿童（62名）和青少年（55名）的循环尿鸟苷素原水平，其中包括73名肥胖者和44名正常体重者。在青春期前，瘦女孩的尿鸟苷素原浓度高于瘦男孩（1111 vs 635，p < 0.001）。在青春期，瘦男性的尿鸟苷素原水平高于瘦女性（1060 vs 698，p < 0.01）。在女孩中，尿鸟苷素原与年龄、坦纳分期、体重、身高、BMI（体重指数）、腰围和血浆瘦素和睾酮水平呈负相关;尿鸟苷素原与游离三碘甲状腺原氨酸呈正相关。在男孩中，尿鸟苷素原与BMI和腰围呈正相关，与高密度脂蛋白胆固醇呈负相关。我们得出结论，性别二型性存在于循环尿鸟苷素水平相对于体重指数。尿鸟苷素也提出了一个相反的循环模式，在青春期在两种性别。
Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut-brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but not in prepubertal children. This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. We analyzed circulating prouroguanylin levels in 117 children (62) and adolescents (55), including 73 with obesity and 44 with normal weight. The pro-uroguanylin concentration is higher in lean girls during pre-puberty versus lean boys (1111 vs 635, p < 0.001). During puberty, pro-uroguanylin levels are higher in lean males with respect to lean females (1060 vs 698, p < 0.01). In girls, a negative correlation exists between prouroguanylin and age, Tanner stage, weight, height, BMI (body mass index), waist circumference and plasma levels of leptin and testosterone; a positive correlation was found between pro-uroguanylin and free triiodothyronine. In boys, a positive correlation was found between pro-uroguanylin and BMI and waist circumference and a negative correlation was found with high density lipoprotein-cholesterol. We conclude that a sexual dimorphism exists in circulating pro-uroguanylin levels with respect to BMI. Uroguanylin presents also an opposed circulating pattern during puberty in both sexes.