Oral Hygiene and Risk of Nasopharyngeal Carcinoma-A Population-Based Case-Control Study in China.
Oral Hygiene and Risk of Nasopharyngeal Carcinoma-A Population-Based Case-Control Study in China.
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DOI：
10.1158/1055-9965.epi-16-0149
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Ye W
中科院分区：
文献类型：
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作者：
Liu Z;Chang ET;Liu Q;Cai Y;Zhang Z;Chen G;Xie SH;Cao SM;Shao JY;Jia WH;Zheng Y;Liao J;Chen Y;Ernberg I;Vaughan TL;Adami HO;Huang G;Zeng Y;Zeng YX;Ye W
口腔健康与鼻咽癌（NPC）风险之间的关系在很大程度上是未知的。进一步了解可能的致病机制和预防措施。我们于2010年至2014年在中国南方进行了一项基于人群的病例对照研究。我们招募了2528例年龄在20-74岁之间的NPC病例和2596例对照，随机从总人口登记中选择，频率与地理区域病例的5年年龄和性别分布相匹配。我们使用结构化问卷对受试者进行访谈，询问口腔健康指标和潜在的混杂因素。我们使用无条件逻辑回归来估计95%置信区间（ci）的多变量调整优势比（ORs）。补牙数量越多，患鼻咽癌的风险越高。充填1 ~ 3颗牙和超过3颗牙与未充填相比，调整后的or分别为1.25 （95% CI: 1.06, 1.49）和1.55 (95% CI: 1.13, 2.12) （P趋势= 0.002）。相反，每天刷牙两次或两次以上的人与每天刷牙一次或更少的人的调整OR为0.62 （95% CI: 0.55, 0.70）。我们发现了与早期首次成人牙齿脱落的年龄有显著的正相关关系。我们的研究表明，一些口腔健康状况不佳的指标与鼻咽癌的风险呈正相关。需要进一步的研究来确认这些发现是否有因果关系，如果有的话，需要进一步解释潜在的机制。改善口腔卫生可能有助于降低鼻咽癌风险
The association between oral health and risk of nasopharyngeal carcinoma (NPC) is largely unknown. Further understanding could shed light on potential pathogenic mechanisms and preventive measures. We conducted a population-based case-control study in southern China between 2010 and 2014. We enrolled 2528 incident NPC cases aged 20–74 years, and 2596 controls, randomly selected from the total population registers, with frequency matching to the 5-year age and sex distribution of the cases by geographic region. We interviewed subjects using a structured questionnaire inquiring about oral health indicators and potential confounding factors. We used unconditional logistic regression to estimate multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CIs). A higher number of filled teeth was associated with an elevated risk of NPC. Individuals with 1 to 3 and more than 3 teeth filled versus none had adjusted ORs of 1.25 (95% CI: 1.06, 1.49) and 1.55 (95% CI: 1.13, 2.12), respectively (P trend = 0.002). Conversely, the adjusted OR for those who brushed teeth twice or more per day vs. once or less per day was 0.62 (95% CI: 0.55, 0.70). We detected a borderline significant positive association with earlier age at first adult tooth loss. Our study suggested a positive association between some indicators of poor oral health and risk of NPC. Further studies are needed to confirm whether the findings are causal and, if so, to further explain the underlying mechanisms. Improvement of oral hygiene might contribute to reducing NPC risk.4