Signal-to-Noise Enhancement in Optical Detection of Single Viruses With Multispot Excitation
Signal-to-Noise Enhancement in Optical Detection of Single Viruses With Multispot Excitation
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DOI：
10.1109/jstqe.2015.2503321
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发表时间：
2016-07-01
影响因子：
4.9
通讯作者：
Schmidt, Holger
中科院分区：
文献类型：
--
作者：
Ozcelik, Damla;Stott, Matthew A.;Schmidt, Holger
We present fluorescence detection of single H1N1 viruses with enhanced signal to noise ratio (SNR) achieved by multispot excitation in liquid-core antiresonant reflecting optical waveguides (ARROWs). Solid-core Y-splitting ARROW waveguides are fabricated orthogonal to the liquid-core section of the chip, creating multiple excitation spots for the analyte. We derive expressions for the SNR increase after signal processing, and analyze its dependence on signal levels and spot number. Very good agreement between theoretical calculations and experimental results is found. SNR enhancements up to 5x10(4) are demonstrated.
