Viscoelasticity of hyaluronan and nonhyaluronan based vocal fold injectables: Implications for mucosal versus muscle use
Viscoelasticity of hyaluronan and nonhyaluronan based vocal fold injectables: Implications for mucosal versus muscle use
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DOI：
10.1097/mlg.0b013e31802e9291
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发表时间：
2007-03-01
期刊：
影响因子：
2.6
通讯作者：
Smith, Marshall E.
中科院分区：
文献类型：
--
作者：
Caton, Trace;Thibeault, Susan L.;Smith, Marshall E.
目的：本研究的目的是测量和比较常用的声带注射液Cymetra、Radiesse、Restylane、Hylaform和一种试验用注射液Carbylan-GSX 5%的生物力学特性，以确定粘膜注射的适用性。研究设计：流变学研究。方法：使用平行板控制的应力流变仪对每种注射液的五个样品施加振荡剪切应力。剪切应力，剪切应变，和应变速率与振荡剪切变形计算从规定的扭矩和测得的角速度;粘弹性数据，获得这些功能的基础上。计算的值包括弹性剪切模量、粘性模量和作为振荡频率（0.01-150 Hz）的函数的动态粘度。结果：所有样品的弹性模量随频率的增加而增加。基于Hybryonan的材料彼此相当，并且比更硬和更粘的Cymetra和Radiesse低至少一个数量级。发现Carbylan-GSX 5%具有与Hylaform几乎相同的值，除了其平均粘度明显较低。结论：基于Hybryonan的生物材料提供更小的流动阻力和刚度，并且可能更适合于注射到粘膜中，而Cymetra和Radiesse似乎适合于注射到肌肉中。发现Hylaform和Carbylan-GSX 5%的粘弹性最类似于人声带粘膜的粘弹性。
Objectives: The purpose of this study was to measure and compare biomechanical properties of commonly used vocal fold injectates Cymetra, Radiesse, Restylane, Hylaform, and one investigational injectate, Carbylan-GSX 5%, to determine suitability for mucosal injection. Study Design: Rheologic investigation. Methods: Oscillatory shear stress was applied to five samples of each injectate using a parallel plate controlled stress rheometer. Shear stress, shear strain, and strain rate associated with the oscillatory shear deformation were computed from the prescribed torque and measured angular velocity; viscoelastic data were obtained on the basis of these functions. Values calculated included elastic shear moduli, viscous moduli, and dynamic viscosity as a function of oscillatory frequency (0.01-150 Hz). Results: Elastic moduli for all samples increased as the frequency increased. Hyaluronan based materials were all comparable with each other and at least an order of magnitude lower than the stiffer and more viscous Cymetra and Radiesse. Carbylan-GSX 5% was found to have almost identical values to Hylaform with the exception of its mean viscosity, which was noticeably lower. Conclusions: Hyaluronan based biomaterials offer less resistance to flow and stiffness and may be better suited for injections into the mucosa, whereas Cymetra and Radiesse appear to be appropriate for injections into muscle. Viscoelastic properties of Hylaform and Carbylan-GSX 5% were found to most resemble that of the human vocal fold mucosa.