Prevalence of pruritus in patients with chronic liver disease: A multicenter study
Prevalence of pruritus in patients with chronic liver disease: A multicenter study
复制标题
DOI：
10.1111/hepr.12978
复制
发表时间：
2018-02-01
影响因子：
4.2
通讯作者：
Eguchi, Yuichiro
中科院分区：
文献类型：
--
作者：
Oeda, Satoshi;Takahashi, Hirokazu;Eguchi, Yuichiro
目的：瘙痒是慢性肝脏疾病的常见合并症。本研究的目的是阐明瘙痒症的患病率及其特点在慢性肝病patients with chronic liver diseases.Methods：共有1631例慢性肝病患者参加了9个联合研究机构之一，从2016年1月至6月入组。我们调查了瘙痒症的患病率，瘙痒的位置，瘙痒持续时间，每日瘙痒波动，季节性瘙痒加剧，治疗药物和治疗效果，使用医学访谈questionnaire.Results：中位年龄为66岁，890（54.6%）例患者为女性。瘙痒症的患病率为40.3%（658/1631），根据基础肝病不同而不同。瘙痒最常见的身体部位是背部（63.1%）。252例（38.3%）患者瘙痒持续时间超过6个月。使用视觉模拟量表评估瘙痒的严重程度，白天高于夜间（中位数，4 vs. 3，P < 0.001）。在296例（45.0%）患者中观察到季节性加重。尽管301例（45.7%）患者接受了抗过敏药物治疗，但57.8%（174/301）的患者报告疗效不足。活动性B型肝炎病毒感染（比值比[OR]，2.51; P = 0.043），原发性胆汁性胆管炎（OR，3.69; P = 0.018），糖尿病（OR，1.57; P = 0.010），天冬氨酸转氨酶≥ 60 U/L结论：慢性肝病患者瘙痒症的患病率因病因不同而不同。基础肝病、天冬氨酸转氨酶>= 60 U/L和合并糖尿病是慢性肝病患者瘙痒的相关因素。
Aim: Pruritus is a common comorbidity in chronic liver disease. The aim of this study was to clarify the prevalence of pruritus and its characteristics in patients with chronic liver disease.Methods: A total of 1631 patients with chronic liver disease who attended one of nine joint-research facilities from January to June 2016 were enrolled. We investigated the prevalence of pruritus, itch location, itch duration, daily itch fluctuation, seasonal itch exacerbation, treatment drugs, and therapeutic effects using a medical interview questionnaire.Results: The median age was 66 years and 890 (54.6%) patients were women. The prevalence of pruritus was 40.3% (658/1631), and it differed according to the underlying liver disease. The most frequent body location for pruritus was on the back (63.1%). Pruritus duration was more than 6 months in 252 (38.3%) patients. The severity of pruritus, assessed using a visual analog scale, was higher during the day than at night (median, 4 vs. 3, P < 0.001). Seasonal exacerbation was observed in 296 (45.0%) patients. Although 301 (45.7%) patients were treated with antipruritic agents, 57.8% (174/301) patients reported an insufficient effect. Active hepatitis B virus infection (odds ratio [OR], 2.51; P = 0.043), primary biliary cholangitis (OR, 3.69; P = 0.018), diabetes (OR, 1.57; P = 0.010), and aspartate aminotransferase >= 60 U/L (OR, 2.06; P = 0.011) were independent factors associated with pruritus.Conclusion: The prevalence of pruritus varies according to the chronic liver disease etiology. Underlying liver disease, aspartate aminotransferase >= 60 U/L, and comorbid diabetes are factors associated with pruritus in patients with chronic liver disease.