A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women
A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women
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DOI：
10.1093/jn/nxab325
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发表时间：
2022-01-01
影响因子：
4.2
通讯作者：
Yamori, Yukio
中科院分区：
文献类型：
--
作者：
Bajerska, Joanna;Lagowska, Karolina;Yamori, Yukio
背景资料：血清炎症细胞因子，特别是TNF-α和IL-6，以及C-反应蛋白（CRP）的浓度升高，通常在绝经后观察到。目的：由于大豆异黄酮可能具有一定的抗炎潜力，本系统综述和随机对照试验（RCT）的荟萃分析的目的是探讨大豆摄入量是否影响绝经后妇女的血清炎症标志物。对PubMed、Web of Science和科克伦图书馆进行了系统性检索，检索时间截止至2020年8月。所有符合以下标准的随机对照试验均包括在内：1）大豆摄入量对炎症标志物影响的研究; 2）任何出版日期; 3）对绝经后妇女进行的研究; 4）有足够的定量数据进行荟萃分析。效应量表示为加权平均差异（WMD）和95% CI。共有24项评估大豆摄入量对CRP、TNF-α和IL-6血清浓度影响的RCT纳入分析。结果：补充大豆可显著降低绝经后妇女CRP水平0.11 mg/L（95%CI：-0.22，-0.004 mg/L; P= 0.0414），但不影响IL-6和TNF-α。当给予天然大豆制品时，CRP浓度显著降低（WMD：-0.23 mg/L; 95% CI：-0.29，-0.17 mg/L; P < 0.001）。这是相当于一个类似的9%的CRP浓度从baseline.Conclusions减少：虽然我们的荟萃分析发现的证据表明，大豆制品显着降低CRP浓度在绝经后妇女，大豆食品及其成分影响炎症生物标志物的机制仍然需要澄清。
Background: Elevated concentrations of serum inflammatory cytokines, specifically TNF-alpha and IL-6, as well as C-reactive protein (CRP), are commonly observed after menopause.Objectives: Because soy isoflavones may have some anti-inflammatory potential, the aim of the present systematic review and meta-analysis of randomized controlled trials (RCTs) was to explore whether soy intake affects serum markers of inflammation in postmenopausal women.Methods: PubMed, Web of Science, and the Cochrane Library were systematically searched up to August 2020. All RCTs that met the following criteria were included: 1) studies of the effects of soy intake on inflammatory markers; 2) any date of publication; 3) conducted on postmenopausal women; 4) with sufficient quantitative data for meta-analysis. Effect sizes were expressed as weighted mean differences (WMDs) and 95% Cls. A total of 24 RCTs assessing the effects of soy intake on serum concentrations of CRP TNF-alpha, and IL-6 were included in the analysis. A random-effects model was used to determine the overall effect.Results: Soy supplementation significantly reduced CRP by 0.11 mg/L in postmenopausal women (95% CI: -0.22, -0.004 mg/L; P= 0.0414), but did not affect IL-6 or TNF-a. Significant reductions in CRP concentration occurred when natural soy products were given (WMD: -0.23 mg/L; 95% CI: -0.29, -0.17 mg/L; P < 0.001). This is equivalent to a similar to 9% reduction in CRP concentration from baseline.Conclusions: Although our meta-analysis found evidence that soy products significantly reduce CRP concentrations in postmenopausal women, the mechanisms by which soy foods and their constituents affect inflammatory biomarkers still need to be clarified.