Oxidative Stress in Stem Cell Aging.
Oxidative Stress in Stem Cell Aging.
复制标题
DOI：
10.1177/0963689717735407
复制
发表时间：
2017-09
影响因子：
3.3
通讯作者：
So KF
中科院分区：
文献类型：
--
作者：
Chen F;Liu Y;Wong NK;Xiao J;So KF
干细胞老化是干细胞逐渐丧失自我更新或分化能力、屈服于衰老或凋亡并最终变得功能耗尽的过程。未解决的氧化应激和伴随的氧化损伤的细胞大分子，包括核酸，蛋白质，脂质，和碳水化合物已被认为有助于干细胞老化。活性氧的过度产生和细胞抗氧化剂储备不足会损害细胞修复和代谢稳态，这是多种衰老相关途径的机械开关。了解这些信号网络的分子触发，调节和结果对于通过靶向干细胞衰老开发衰老相关疾病的新疗法至关重要。在这里，我们探讨干细胞衰老生物学的关键特征，重点是氧化应激在分子水平上衰老过程中的作用。作为移植中干细胞细胞保护的一个概念，我们还讨论了如何在移植前或移植过程中系统地增强内源性抗氧化能力，可能会提高临床治疗的疗效。最后，未来的方向阐明控制氧化应激和开发预防/治疗策略对干细胞衰老进行了讨论。
Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed.
登录
查看更多内容
影响因子：
10.3
作者：
Chen, Yen-Ta;Chiang, Hsin-Ju;Yip, Hon-Kan
通讯作者：
Yip, Hon-Kan
影响因子：
8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
高葡萄糖通过上调自噬来诱导骨髓来源的间充质干细胞衰老。
影响因子：
3.7
作者：
Chang TC;Hsu MF;Wu KK
通讯作者：
Wu KK
DOI：
10.1186/2046-2395-3-6
发表时间：
2014
期刊：
Longevity & healthspan
影响因子：
--
作者：
Dai DF;Chiao YA;Marcinek DJ;Szeto HH;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
4.2
作者：
Cal, Jieru;Yu, Xiaofang;Ding, Xiaoqiang
通讯作者：
Ding, Xiaoqiang