Relation of renal impairment and haemorrhagic diathesis to endotoxaemia in fulminant hepatic failure.
Relation of renal impairment and haemorrhagic diathesis to endotoxaemia in fulminant hepatic failure.
复制标题
肾功能损害和出血素质与暴发性肝衰竭中内毒素血症的关系。
DOI：
10.1016/s0140-6736(74)92711-1
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发表时间：
1974
期刊：
影响因子：
168.9
通讯作者：
Roger Williams
中科院分区：
文献类型：
--
作者：
S. Wilkinson;B. Gazzard;V. Arroyo;H. Moodie;Roger Williams
通过总结性鲎裂解液检测，在 22 名连续暴发性肝衰竭患者中，有 14 名发现内毒素血症。在大多数情况下，没有其他革兰氏阴性菌感染的证据，内毒素血症可能是由于肝脏对通常从胃肠道吸收的毒素的清除能力受损所致。内毒素血症的发生与肾功能衰竭和血管内凝血的发生之间存在统计学上显着的相关性，这可以通过内毒素作为肾血管收缩剂和哈格曼因子激活剂的已知特性来解释。
Endotoxaemia, as detected by theSummaryLimuluslysate assay, was found in 14 of 22 consecutive patients with fulminant hepatic failure. In most cases there was no other evidence of gram-negative infection and the endotoxaemia may have been due to impaired hepatic clearance of toxins normally absorbed from the gastrointestinal tract. There were statistically significant correlations between the occurrence of endotoxaemia and the development of renal failure and intravascular coagulation, which may be explained by the known properties of endotoxin as a renal vasoconstrictor and an activator of Hageman factor.