Drug therapy for acquired pendular nystagmus in multiple sclerosis
Drug therapy for acquired pendular nystagmus in multiple sclerosis
复制标题
多发性硬化症获得性摆动性眼球震颤的药物治疗
DOI：
10.1007/pl00007728
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发表时间：
1996
影响因子：
6
通讯作者：
Marianne Dieterich
中科院分区：
文献类型：
--
作者：
M. Starck;H. Albrecht;W. Pöllmann;A. Straube;Marianne Dieterich
摘要获得性摆动性眼球震颤（APN）常伴有失视和静态视力下降。APN的治疗方法仍然存在争议，并且没有普遍接受的治疗方法。我们测试了14例患有多发性硬化引起的APN数年; 12例患者表现为固定摆动性眼球震颤（在固定过程中增加），2例表现为自发性摆动性眼球震颤。所有11例固定性摆动性眼震患者在给予谷氨酸拮抗剂美金刚胺后，眼震完全停止。与此相反，东莨菪碱没有引起（6/8）或仅引起轻微（10-50%）眼震减少（2/8）。结论是美金刚是APN的安全治疗选择。
Abstract Acquired pendular nystagmus (APN) is regularly accompanied by oscillopsia and impairment of static visual acuity. Therapeutic approaches to APN remain controversial, and there is no generally accepted therapeutic approach. We tested 14 patients who had suffered from APN caused by multiple sclerosis for several years; 12 patients presented with fixational pendular nystagmus (increasing during fixation) and 2 with spontaneous pendular nystagmus. All 11 patients with fixational pendular nystagmus who were given memantine, a glutamate antagonist, experienced complete cessation of the nystagmus. In contrast, scopolamine caused no (6 of 8) or only a minor (10–50%) reduction of the nystagmus (2 of 8). It was concluded that memantine is a safe treatment option for APN.
影响因子：
2.5
作者：
ROBINSON, FR;STRAUBE, A;FUCHS, AF
通讯作者：
FUCHS, AF