Two new flavonol glycosides from Epimedium koreanum Nakai
Two new flavonol glycosides from Epimedium koreanum Nakai
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DOI：
10.1080/10286020902867151
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Yao, Xin-Sheng
中科院分区：
文献类型：
--
作者：
Jiang, Fang;Wang, Xin-Luan;Yao, Xin-Sheng
从朝鲜淫羊藿（Epimedium koreanum Nakai）水提物中分离得到两个新的黄酮醇苷类化合物，分别命名为淫羊藿苷B（1）和淫羊藿苷C（2）。根据化学和光谱方法确定了这两个新化合物的结构（ESI-MS，1D和2D NMR）为5-羟基-4 '-甲氧基-8-（2-甲氧基苯基）-2-（4-甲氧基苯基）-2-（4-甲氧基苯基）-2-（4-甲氧基苯基）-2-（三氟甲基）-2-（三氟甲基）苯基。（β-羟基-，β-二甲基）-丙基-3-O-β-l-吡喃鼠李糖基-黄酮醇-7-O-β-d-吡喃葡萄糖苷（1）和5-羟基-4 '-甲氧基-8-（β-甲氧基-，β-二甲基）-丙基-3-O-β-D-吡喃葡萄糖基（13）-β-L-吡喃鼠李糖基-黄酮醇-7-O-β-D-吡喃葡萄糖苷（2）。使用UMR 106细胞测试所有九种化合物对增殖和碱性磷酸酶（ALP）活性的影响。结果表明，5个化合物对细胞增殖和ALP活性均有促进作用，提示它们有可能成为治疗骨质疏松症的先导化合物。
Two new flavonol glycosides, named icarisid B (1) and icarisid C (2), along with seven known flavonol glycosides were isolated from the bioassay-directed fractions of the aqueous extract of Epimedium koreanum Nakai. The structures of the two new compounds were established on the basis of chemical and spectroscopic methods (ESI-MS, 1D, and 2D NMR) as 5-hydroxyl-4'-methoxy-8-(-hydroxyl-,-dimethyl)-propyl-3-O--l-rhamnopyranosyl-flavonol-7-O--d-glucopyranoside (1) and 5-hydroxyl-4'-methoxy-8-(-methoxy-,-dimethyl)-propyl-3-O--d-glucopyranosyl(13)--l-rhamnopyranosyl-flavonol-7-O--d-glucopyranoside (2), respectively. All the nine compounds were tested for their effects on proliferation and alkaline phosphatase (ALP) activity using UMR106 cells. As a result, five compounds showed stimulating effects on both the proliferation and ALP activity, which suggested that they might be used as potential leading compounds to cure osteoporosis.