ANTIBODIES TO ENDOTHELIAL-CELLS IN DERMATOMYOSITIS - ASSOCIATION WITH INTERSTITIAL LUNG-DISEASE
ANTIBODIES TO ENDOTHELIAL-CELLS IN DERMATOMYOSITIS - ASSOCIATION WITH INTERSTITIAL LUNG-DISEASE
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DOI：
10.1136/bmj.302.6781.880-a
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发表时间：
1991-04-13
影响因子：
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通讯作者：
HUGHES, GRV
中科院分区：
文献类型：
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作者：
CERVERA, R;RAMIREZ, G;HUGHES, GRV
虽然有强有力的证据表明，细胞免疫在多发性肌炎的发病机制中起着重要作用，内皮损伤似乎是皮肌炎的免疫病理学标志之一，即使在疾病的早期阶段。因此，毛细血管损害目前被认为是诊断皮肌炎的一个重要标准，与是否有皮肤受累无关。我们调查的患病率和特点的抗体内皮细胞皮肌炎患者，以评估其临床和病理遗传significance.Patients，方法和结果我们研究了18例（12名女性和6名男性，平均年龄51（SD 7）岁）皮肌炎活检证实的临床和实验室特征。所有患者的肌肉活检标本均有炎症和坏死改变，毛细血管损伤明显。此外，本研究还纳入了22例患有其他类型肌病（多发性肌炎和先天性、中毒性和甲状腺功能减退性肌病）的患者（15例女性和7例男性，平均年龄36（SD 10）岁）和50例年龄和性别匹配的健康献血者。
Though there is strong evidence that cellular immunity plays a major part in the pathogenesis of polymyositis, endothelial damage seems to be one of the immuno-pathological hallmarks in dermatomyositis, even in early stages of the disease.'2For this reason capillary damage is currently considered to be an important criterion in diagnosing dermatomyositis, independent of the presence or absenceofovert skin involvement. We investigated the prevalence and characteristics of antibodies to endothelial cells in patients with dermatomyositis to assess their clinical and patho-genetic significance.Patients, methods, and results We studied the clinical and laboratory features of 18 patients (12 female and six male, mean age 51 (SD 7) years) with dermatomyositis confirmed by biopsy. All biopsy specimens of muscle had inflammatory and necrotic changes, and capillary damage was evident in all patients. In addition, 22 patients (15 female and seven male, mean age 36 (SD 10) years) with other types of myopathy (polymyositis and congenital, toxic, and hypothyroid myopathies) and 50 age and sex matched healthy blood donors were included in the study.