A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine.
A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine.
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叙利亚仓鼠的一种强效胰腺致癌物：N-亚硝基双(2-氧代丙基)胺。
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
U. Mohr
中科院分区：
文献类型：
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作者：
P. Pour;J. Althoff;F. Krüger;U. Mohr
N-亚硝基双（2-氧代丙基）胺（BOP）是二正丙基亚硝胺的另一种假定β-代谢产物，在接受每周一次皮下注射的叙利亚仓鼠中，早在13周时就诱导了胰管腺瘤和腺癌的高发病率，在接受单次皮下注射的叙利亚仓鼠中，28周后诱导了少数胰腺腺瘤。与相关化合物N-亚硝基双（2-羟丙基）胺和N-亚硝基双（2-乙酰氧基丙基）胺（它们也是胰腺致癌物）相比，BOP仅引起肺、肝和肾的少数肿瘤，而鼻腔、喉和气管中无肿瘤。因此，这些结果表明，在开发一个更具体的模型胰腺癌的研究进展。
N-Nitrosobis(2-oxopropyl)amine (BOP), a further postulated beta-metabolite of di-n-propylnitrosamine, induced a high incidence of pancreatic duct adenomas and adenocarcinomas as early as 13 weeks in Syrian hamsters receiving weekly sc injections for life and a few pancreatic adenomas, after 28 weeks, in those given a single sc dose. Compared to related compounds, N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-acetoxy-propyl)amine which are also pancreatic carcinogens, BOP induced only a few neoplasms of the lung, liver, and kidney and none in the nasal cavity, larynx, and trachea. The results therefore indicate progress in developing a more specific model for pancreatic carcinogenesis studies.